Exposure to low dose ionising radiation: Molecular and clinical consequences

被引：27

作者：

Martin, Lynn M. ^{[1
,2
,3
]}

Marples, Brian ^{[4
]}

Lynch, Thomas H. ^{[1
,2
,3
]}

Hollywood, Donal ^{[1
,2
,3
]}

Marignol, Laure ^{[1
,2
,3
]}

机构：

[1] Univ Dublin Trinity Coll, Dublin 8, Ireland

[2] Univ Dublin Trinity Coll, Prostate Mol Oncol Res Grp, Discipline Radiat Therapy, Dublin 8, Ireland

[3] Univ Dublin Trinity Coll, Inst Mol Med, Dublin 8, Ireland

[4] William Beaumont Hosp, Dept Radiat Oncol, Royal Oak, MI 48073 USA

来源：

CANCER LETTERS | 2014年 / 349卷 / 01期

关键词：

Ionising radiation; Low dose; Hypersensitivity; Cell cycle arrest; DNA damage; HAMSTER V79 CELLS; HYPER-RADIOSENSITIVITY; MISMATCH REPAIR; INCREASED RADIORESISTANCE; FRACTIONATED RADIOTHERAPY; PRIMARY KERATINOCYTES; ADAPTIVE RESPONSE; CELLULAR-RESPONSE; MAMMALIAN-CELLS; CANCER-CELLS;

D O I：

10.1016/j.canlet.2013.12.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HAS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect. (c) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：98 / 106

页数：9

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