Automation and control issues in the design of a pharmaceutical pilot plant

被引：2
|
作者：
Bequette, BW
Holihan, S
Bacher, S
机构：
[1] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA
[2] Merck Res Labs, Rahway, NJ USA
来源：
CONTROL ENGINEERING PRACTICE | 2004年 / 12卷 / 07期
关键词：
chemical process; batch reactor; process control; simulation; design;
D O I：
10.1016/j.conengprac.2004.01.002
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
The role of process design and automation for a pilot plant facility in the pharmaceutical industry is discussed. Vessels range from 80 to 5000 1, with various materials of fabrication. A simulator was developed to predict limitations to operating performance. Challenges to operation and control of vessels in this facility are discussed, and illustrative simulation results are presented. Controller tuning parameter relationships as a function of reactor scale are developed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：901 / 908
页数：8
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