In Vitro Susceptibility of Mycobacterium tuberculosis to Trimethoprim and Sulfonamides in France

被引：19

作者：

Ameen, Sirwan Muhammed

Drancourt, Michel ^{[1
]}

机构：

[1] Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, CNRS, UMR 6236, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 12期

关键词：

SULFAMETHOXAZOLE;

D O I：

10.1128/AAC.01683-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Five type strains and 55 Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. Two M. canettii isolates uniquely yielded silent mutations C-156 -> T and G(238)-> C in the folP1 gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.

引用

页码：6370 / 6371

页数：2

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