Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population

被引：1
|
作者：
Liu, Shiguo [1 ,2 ,3 ]
Wang, Xueqin [4 ]
Xu, Longqiang [5 ]
Zheng, Lanlan [4 ]
Ge, Yinlin [4 ]
Ma, Xu [6 ,7 ,8 ]
机构：
[1] Qingdao Univ, Coll Med, Affiliated Hosp, Shandong Prov Key Lab Metab Dis, Qingdao 266003, Peoples R China
[2] Qingdao Univ, Coll Med, Affiliated Hosp, Inst Clin Res, Qingdao 266003, Peoples R China
[3] Qingdao Univ, Coll Med, Affiliated Hosp, Genet Lab, Qingdao 266003, Peoples R China
[4] Qingdao Univ, Sch Med, Qingdao 266071, Peoples R China
[5] Qingdao Univ, Coll Med, Dept Psychiat, Qingdao 266021, Peoples R China
[6] Peking Union Med Coll, Grad Sch, Beijing 100021, Peoples R China
[7] Natl Res Inst Family Planning, Beijing 100081, Peoples R China
[8] World Hlth Org Collaborating Ctr Res Human Reprod, Beijing, Peoples R China
来源：
NEUROCASE | 2015年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
MAOA; VNTR; TDT; TS; TRANSMISSION;
D O I：
10.1080/13554794.2013.873061
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To clarify the association of monoamine oxidase A- variable number of tandem repeat (MAOA-pVNTR) with susceptibility to Tourette's syndrome (TS) in Chinese Han population we discuss the genetic contribution of MAOA-VNTR in 141 TS patients including all their parents in Chinese Han population using transmission disequilibrium test (TDT) design. Our results revealed that no significant association was found in the MAOA gene promoter VNTR polymorphism and TS in Chinese Han population (TDT=1.515, df=1, p> 0.05). The negative result may be mainly due to the small sample size, but we don't deny the role of gene coding serotonergic or monoaminergic structures in the etiology of TS.
引用
收藏
页码：106 / 108
页数：3
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