The purpose of this review was to identify whether supplementation with prebiotics and/or probiotics help prevent the development or reduce the severity of atopic dermatitis in children less than three years of age. Since 1997, immunostimulatory supplements, such as prebiotics and probiotics, have been investigated. Various supplementations include probiotics (single strain or mix), probiotics with formula, probiotics mix with prebiotics, and prebiotics. In this narrative review, we examined 13 key articles on prebiotics and/or probiotics, and their effects on infant atopic dermatitis. Among the selected studies, a total of 3,023 participants received supplements or placebo. Eight out of the 13 (61.5%) studies reported a significant effect on the prevention of atopic dermatitis after supplementation with probiotics and/or prebiotics. Five out of the 13 (38.5%) studies indicated significant reduction in the severity of atopic dermatitis after supplementation. Based on the available studies, supplementation with certain probiotics (Lactobacillus rhamnosus GG) appears to be an effective approach for the prevention and reduction in severity of atopic dermatitis. A mix of specific probiotic strains prevented atopic dermatitis among infants. Based on studies with prebiotics, there was a long-term reduction in the incidence of atopic dermatitis. Supplementation with prebiotics and probiotics appears useful for the reduction in the severity of atopic dermatitis. Additional interventional studies exploring prebiotics and probiotics are imperative before recommendations can be made.
机构:
Carol Davila Univ Med & Pharm, Internal Med, Bucharest 050474, RomaniaBeziers Hosp Ctr, Pediat Dept, F-34500 Beziers, France
Leru, Poliana
Ali, Selda
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Carol Davila Univ Med & Pharm, Allergy Dept, Bucharest 050474, Romania
Dr Carol Davila Clin Nephrol Hosp, Allergy Dept, Bucharest 010731, RomaniaBeziers Hosp Ctr, Pediat Dept, F-34500 Beziers, France
Ali, Selda
Corcea, Sabina
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Carol Davila Univ Med & Pharm, Allergy Dept, Bucharest 050474, RomaniaBeziers Hosp Ctr, Pediat Dept, F-34500 Beziers, France
Corcea, Sabina
Bumbacea, Roxana
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机构:
Carol Davila Univ Med & Pharm, Allergy Dept, Bucharest 050474, Romania
Dr Carol Davila Clin Nephrol Hosp, Allergy Dept, Bucharest 010731, RomaniaBeziers Hosp Ctr, Pediat Dept, F-34500 Beziers, France