Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

被引：109

作者：

Powers, JP ^{[1
]}

Li, SY ^{[1
]}

Jaen, JC ^{[1
]}

Liu, JQ ^{[1
]}

Walker, NPC ^{[1
]}

Wang, ZL ^{[1
]}

Wesche, H ^{[1
]}

机构：

[1] Amgen Inc, 1120 Vet Blvd, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

关键词：

IRAK-4; kinase; inflammation; kinase inhibitor;

D O I：

10.1016/j.bmcl.2006.03.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2842 / 2845

页数：4

共 50 条

[1] A case of chilblains associated with interleukin-1 receptor-associated kinase-4 deficiency
Gurung, P.
Lee, A.
Armon, K.
Millington, G.
BRITISH JOURNAL OF DERMATOLOGY, 2015, 173 : 154 - 155
[2] Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4
Wang, Zhulun
Sun, Daqing
Johnstone, Sheree
Cao, Zhaodan
Gao, Xiong
Jaen, Juan C.
Liu, Jingqian
Lively, Sarah
Miao, Shichang
Sudom, Athena
Tomooka, Craig
Walker, Nigel P. C.
Wright, Matthew
Yan, Xuelei
Ye, Qiuping
Powers, Jay P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (23) : 5546 - 5550
[3] Anti-Inflammatory Profile of AS2444697, A Novel Interleukin-1 Receptor-Associated Kinase-4 Inhibitor
Imanishi, Junko
Ishikawa, Takeshi
Imamura, Emiko
Mizuhara, Hidekazu
Iwaoka, Haruna
Evelyn, Ball
Inami, Hiroshi
Mizutani, Tsuyoshi
Watanabe, Junko
Usuda, Hiroyuki
Nagashima, Shinya
Ito, Tomonori
Kontani, Toru
Shimizu, Yasuaki
Mutoh, Seitaro
ARTHRITIS AND RHEUMATISM, 2011, 63 (10): : S390 - S390
[4] Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency
Szabo, Judit
Dobay, Orsolya
Erdos, Melinda
Borbely, Agnes
Rozgonyi, Ferenc
Marodi, Laszlo
JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 56 (06) : 863 - 865
[5] Structure-Function Similarities between a Plant Receptor-like Kinase and the Human Interleukin-1 Receptor-associated Kinase-4
Klaus-Heisen, Doerte
Nurisso, Alessandra
Pietraszewska-Bogiel, Anna
Mbengue, Malick
Camut, Sylvie
Timmers, Ton
Pichereaux, Carole
Rossignol, Michel
Gadella, Theodorus W. J.
Imberty, Anne
Lefebvre, Benoit
Cullimore, Julie V.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (13) : 11202 - 11210
[6] Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4
Eda, Hiroyuki
Burnette, Barry L.
Shimada, Hideaki
Hope, Heidi R.
Monahan, Joseph B.
CELL BIOLOGY INTERNATIONAL, 2011, 35 (04) : 355 - 358
[7] Anti-inflammatory effect of berkeleyacetal C through the inhibition of interleukin-1 receptor-associated kinase-4 activity
Etoh, Tadahiro
Kim, Yong Pil
Tanaka, Haruo
Hayashi, Masahiko
EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 698 (1-3) : 435 - 443
[8] Variations of interleukin-1 receptor-associated kinase-4 encoding gene were not associated with post-bronchiolitis lung function
Riikonen, Riikka
Lauhkonen, Eero
Terasjarvi, Johanna
Tormanen, Sari
Nuolivirta, Kirsi
He, Qiushui
Korppi, Matti
ACTA PAEDIATRICA, 2021, 110 (05) : 1591 - 1593
[9] Temozolomide-modulated glioma proteome: Role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivity
Kumar, Durairaj M.
Patil, Vikas
Ramachandran, Bini
Nila, Murugesan V.
Dharmalingam, Kuppamuthu
Somasundaram, Kumaravel
PROTEOMICS, 2013, 13 (14) : 2113 - 2124
[10] The Role of interleukin-1 receptor-associated kinase 4 in drug addiction
Wu, Ruyan
Liu, Jian-Feng
Vu, Jimmy
Johnson, Bernard
Li, Jun-Xu
FASEB JOURNAL, 2019, 33

← 1 2 3 4 5 →