Cutaneous Human Papillomavirus in Head and Neck Squamous Cell Carcinomas

被引:39
|
作者
Lindel, Katja [1 ]
Helmke, Burkhard [2 ]
Simon, Christian [3 ]
Weber, Klaus J. [1 ]
Debus, Juergen [1 ]
de Villiers, Ethel-Michele [4 ]
机构
[1] Heidelberg Univ, Dept Radiat Oncol & Radiotherapy, D-69120 Heidelberg, Germany
[2] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany
[3] Heidelberg Univ, Dept Otorhinolaryngol Head & Neck Surg, D-69120 Heidelberg, Germany
[4] Deutsch Krebsforschungszentrum, Div Tumorvirus Characterisat, D-69120 Heidelberg, Germany
关键词
Cutaneous HPV; Head and neck cancer; Risk factor; Radiochemotherapy; EPIDERMODYSPLASIA-VERRUCIFORMIS; PHYSICAL STATUS; HPV; 16; CANCER; DNA; ASSOCIATION; PREVALENCE; TUMORS; RISK; IDENTIFICATION;
D O I
10.1080/07357900802653456
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To evaluate the prevalence and meaning of cutaneous human papillomavirus (HPV) types in HNSCC 51 patients were analyzed for the prevalence of cutaneous as well as mucosal HPV. HPV DNA was demonstrated in 18 (35%) of 51 tumors. The majority of these HPV types belong to so-called cutaneous HPV types, whereas only HPV 6 and HPV 16 were from the mucosal HPV types. A possible role for cutaneous HPV types as co-factors in the oncogenesis of HNSCC remains to be elucidated and may be relevant for future strategies of cancer prevention.
引用
收藏
页码:781 / 787
页数:7
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