Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase

被引：0
|
作者：
Bajgar, J
Skopec, F
Herink, J
Patocka, J
Kvetina, J
机构：
[1] Mil Med Acad, Hradec Kralove 50001, Czech Republic
[2] Charles Univ, Fac Med, Hradec Kralove, Czech Republic
[3] PROMEDCS, Inst Expt Biopharm, Hradec Kralove, Czech Republic
[4] AV CR, Hradec Kralove, Czech Republic
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 1999年 / 18卷
关键词：
hippocampus; basal ganglia; rat; choline acetyltransferase;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 5-days treated with L-carnitine and then with one administration of 7-MEOTA. Both compounds increased ChAT activity when administered separately. S-day treatment of CRT followed by administration of 7-MEOTA normalized ChAT activity.
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页码：3 / 6
页数：4
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