o-carboranyl derivatives of 1,3,5-triazines

被引：0

作者：

Lim, HG ^{[1
]}

Lee, JD ^{[1
]}

Lee, YJ ^{[1
]}

Lee, CH ^{[1
]}

Nakamura, H ^{[1
]}

Lee, SH ^{[1
]}

Lee, CH ^{[1
]}

Jun, B ^{[1
]}

Ko, J ^{[1
]}

Kang, SO ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Chochiwon, Chung Nam, South Korea

来源：

RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY | 2002年

关键词：

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Our objective was to design and synthesize substituted o-carboranes carrying the 1,3,5-s-triazine units as potential BNCT agents. The preliminary results indicated that selective substitution was successful, and the structural AB(2) or A(2)B type was used as the starting point for the generation of biologically active species. In the first series, the influence of the structural changes in the central core unit was investigated. Thus, a procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of o-carborane was elucidated. As a result, a variety of mono-, di-, and tri-substituted s-triazines were produced in good yield. In the second series, the effect of additional amine substituents on the 1,3,5-s-triazine was studied.

引用

页码：37 / 42

页数：6

共 50 条

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Lee, CH
Lim, HG
Lee, JD
Lee, YJ
Jaejung, K
Nakamura, H
Kang, SO
[J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2003, 17 (6-7) : 539 - 548
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[4] CONDENSED 1,3,5-TRIAZINES - 1,3,4-THIADIAZOLO[3,2-A]-1,3,5-TRIAZINES AND ISOXAZOLO[2,3-A]-1,3,5-TRIAZINES
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[6] SYNTHESIS OF 1,3,5-TRIAZINES FROM AMINO ACID DERIVATIVES
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[7] O-CARBORANYL DERIVATIVES OF BORON COMPOUNDS
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[J]. INORGANIC CHEMISTRY, 1965, 4 (06) : 910 - &
[8] NUCLEOSIDES OF SUBSTITUTED 1,3,5-TRIAZINES
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[9] SOME SUBSTITUTED 1,3,5-TRIAZINES
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[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1965, (FEB): : 1113 - &
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