Antithrombotic Therapy for Peripheral Artery Disease

被引:41
|
作者
Hussain, Mohamad A. [1 ,2 ,3 ]
Al-Omran, Mohammed [2 ,3 ,4 ]
Creager, Mark A. [5 ]
Anand, Sonia S. [6 ]
Verma, Subodh [2 ,7 ]
Bhatt, Deepak L. [1 ,8 ,9 ,10 ,11 ,12 ,13 ,14 ,15 ,16 ,17 ,18 ,19 ,20 ]
机构
[1] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA
[2] Univ Toronto, Dept Surg, Toronto, ON, Canada
[3] St Michaels Hosp, Li Ka Shing Knowledge Inst, Div Vasc Surg, Toronto, ON, Canada
[4] King Saud Univ, Dept Surg, Riyadh, Saudi Arabia
[5] Dartmouth Hitchcock Med Ctr, Geisel Sch Med Dartmouth, Lebanon, NH 03766 USA
[6] McMaster Univ, Hamilton Hlth Sci, Hamilton, ON, Canada
[7] St Michaels Hosp, Li Ka Shing Knowledge Inst, Div Cardiac Surg, Toronto, ON, Canada
[8] Harvard Med Sch, Boston, MA USA
[9] Advisory Board Cardax, Elsevier Practice Update Cardiol Medscape Cardiol, Washington, DC 20037 USA
[10] Boston VA Res Inst, Boston, MA 02130 USA
[11] Soc Cardiovasc Patient Care, Washington, DC 20037 USA
[12] Amer Heart Assoc, Qual Oversight Comm, Dallas, TX 75231 USA
[13] Mayo Clin, Monitoring Comm, Duke Clin Res Inst, Harvard Clin Res Inst,Cleveland Clin, Rochester, MI 55905 USA
[14] Populat Hlth Res Inst, Hamilton, ON, Canada
[15] NCDR ACTION Registry, Steering Comm, Washington, DC 20037 USA
[16] VA CART Res & Publicat Comm, Washington, DC 20420 USA
[17] Boston Sci, Biotronik, Marlborough, MA 01752 USA
[18] St Jude Med, St Paul, MN 55117 USA
[19] Abbott, Chicago, IL 76621 USA
[20] Amer Coll Cardiol, Washington, DC 20037 USA
关键词
DUAL-ANTIPLATELET THERAPY; CRITICAL LIMB ISCHEMIA; PERCUTANEOUS CORONARY INTERVENTION; THROMBIN-RECEPTOR ANTAGONIST; CARDIOVASCULAR EVENT RATES; MYOCARDIAL-INFARCTION; ENDOVASCULAR THERAPY; COLLABORATIVE METAANALYSIS; SECONDARY PREVENTION; ORAL ANTICOAGULANT;
D O I
10.1016/j.jacc.2018.03.483
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peripheral artery disease (PAD) affects over 200 million people globally and is a cause of significant morbidity, mortality, and disability due to limb loss. Although secondary prevention with antithrombotic therapy is a mainstay of treatment to prevent adverse cardiovascular events, PAD patients are often undertreated with antithrombotic agents. Furthermore, there is a paucity of high-quality data from randomized controlled trials of PAD patients, leading to wide variations in clinical practice and guideline recommendations. Recently, there have been important advances that have further increased the number of antiplatelet and anticoagulant choices potentially available for patients with PAD. In this context, this paper aims to summarize the current available evidence for the safety and efficacy of various antithrombotic agents in PAD, and discuss how to integrate this emerging evidence into actual clinical practice. An evidenced-based approach to PAD patients is essential to achieve optimal outcomes, weighing cardiovascular and limb benefits against bleeding risks. (C) 2018 by the American College of Cardiology Foundation.
引用
收藏
页码:2450 / 2467
页数:18
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