Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

被引：3
|
作者：
Li, R. J. [1 ]
Li, M. [1 ]
Liu, G. J. [1 ]
Guo, Y. W. [1 ]
Bai, H. [1 ]
Xiao, P. [1 ]
Mei, J. Z. [1 ]
机构：
[1] Zhengzhou Peoples Hosp, Dept Med Oncol, Zhengzhou, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2016年 / 15卷 / 01期
关键词：
ERCC5; Polymorphism; Gastric cancer; NUCLEOTIDE EXCISION-REPAIR; LUNG-CANCER; EXPRESSION; XPG; CARCINOMA;
D O I：
10.4238/gmr.15017510
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs17655 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism analysis. By conditional logistic regression analysis, the GG genotype of rs17655 was found to be associated with an elevated risk of gastric cancer in a codominant model, and the adjusted OR (95% CI) was 1.96 (1.10-3.50). Moreover, in a dominant model, the CG + GG genotype of rs17655 was correlated with an increased risk of gastric cancer compared to the CC genotype (OR = 1.48; 95% CI = 1.00-2.22). rs1047768 and rs751402 were not significantly correlated with an increased or decreased gastric cancer risk.
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页数：6
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