The Phosphodiesterase-9 Inhibitor BI 409306 Attenuates Social Interaction and Dopaminergic Deficits in Adult Offspring of poly(I:C)-Based Maternal Immune Activation Neurodevelopmental Mouse Model

被引：0
|
作者：
Arban, Roberto [1 ]
Richetto, Juliet [2 ]
Scarborough, Joseph [2 ]
Dorner-Ciossek, Cornelia [1 ]
Rosenbrock, Holger [1 ]
Meyer, Urs [2 ]
机构：
[1] Boeheringer Ingelheim GmbH & Co KG, Biberach, Germany
[2] Univ Zurich Vetsuisse, Inst Pharmacol & Toxicol, Zurich, Switzerland
来源：
BIOLOGICAL PSYCHIATRY | 2019年 / 85卷 / 10期
关键词：
PDE9; Inhibitor; Schizophrenia; Maternal Immune Activation; Pharmacology;
D O I：
10.1016/j.biopsych.2019.03.939
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
S188
引用
收藏
页码：S369 / S370
页数：2
相关论文
共 6 条
  • [1] THE PHOSPHODIESTERASE-9 INHIBITOR BI 409306 ATTENUATES SOCIAL INTERACTION AND DOPAMINERGIC DEFICITS IN ADULT OFFSPRING OF POLY(I:C)-BASED MATERNAL IMMUNE ACTIVATION NEURODEVELOPMENTAL MOUSE MODEL
    Richetto, Juliet
    Scarborough, Joseph
    Arban, Roberto
    Dorner-Ciossek, Cornelia
    Rosenbrock, Holger
    Meyer, Urs
    [J]. SCHIZOPHRENIA BULLETIN, 2019, 45 : S262 - S262
  • [2] Symptomatic and Preventive Effects of the PDE9 Inhibitor Bi 409306 Against Social Interaction and Dopaminergic Deficits in Adult Offspring From a Neurodevelopmental Mouse Model
    Richetto, Juliet
    Scarborough, Joseph
    Arban, Roberto
    Sand, Michael
    Dorner-Ciossek, Cornelia
    Rosenbrock, Holger
    Meyer, Urs
    [J]. NEUROPSYCHOPHARMACOLOGY, 2019, 44 (SUPPL 1) : 401 - 402
  • [3] Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders
    Scarborough, Joseph
    Mattei, Daniele
    Dorner-Ciossek, Cornelia
    Sand, Michael
    Arban, Roberto
    Rosenbrock, Holger
    Richetto, Juliet
    Meyer, Urs
    [J]. NEUROPSYCHOPHARMACOLOGY, 2021, 46 (08) : 1526 - 1534
  • [4] Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders
    Joseph Scarborough
    Daniele Mattei
    Cornelia Dorner-Ciossek
    Michael Sand
    Roberto Arban
    Holger Rosenbrock
    Juliet Richetto
    Urs Meyer
    [J]. Neuropsychopharmacology, 2021, 46 : 1526 - 1534
  • [5] Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders
    Osborne, Ashleigh L.
    Solowij, Nadia
    Babic, Ilijana
    Lum, Jeremy S.
    Huang, Xu-Feng
    Newell, Kelly A.
    Weston-Green, Katrina
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2019, 81 : 574 - 587
  • [6] Poly(I:C) Challenge Alters Brain Expression of Oligodendroglia-Related Genes of Adult Progeny in a Mouse Model of Maternal Immune Activation
    Zhang, Xiao-Fan
    Chen, Ting
    Yan, Aifen
    Xiao, Jia
    Xie, Yong-Li
    Yuan, Jing
    Chen, Pin
    Wong, Anderson On-Lam
    Zhang, Yang
    Wong, Nai-Kei
    [J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 13
1