In social science research, a common topic in multiple regression analysis is to compare the squared multiple correlation coefficients in different populations. Existing methods based on asymptotic theories (Olkin & Finn, 1995) and bootstrapping (Chan, 2009) are available but these can only handle a 2-group comparison. Another method based on structural equation modeling (SEM) has been proposed recently. However, this method has three disadvantages. First, it requires the user to explicitly specify the sample R-2 as a function in terms of the basic SEM model parameters, which is sometimes troublesome and error prone. Second, it requires the specification of nonlinear constraints, which is not available in some popular SEM software programs. Third, it is for a 2-group comparison primarily. In this article, a 2-stage SEM method is proposed as an alternative. Unlike all other existing methods, the proposed method is simple to use, and it does not require any specific programming features such as the specification of nonlinear constraints. More important, the method allows a simultaneous comparison of 3 or more groups. A real example is given to illustrate the proposed method using EQS, a popular SEM software program.