Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?

被引：16

作者：

Fulka, Helena ^{[1
,2
]}

Kyogoku, Hirohisa ^{[3
]}

Zatsepina, Olga ^{[4
]}

Langerova, Alena ^{[5
]}

Fulka, Josef, Jr. ^{[1
]}

机构：

[1] Inst Anim Sci, Prague, Czech Republic

[2] Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic

[3] RIKEN, Ctr Dev Biol, Kobe, Hyogo, Japan

[4] Shemyakin Ovchinikov Inst Bioorgan Chem, Moscow, Russia

[5] GENNET, Prague, Czech Republic

来源：

TRENDS IN MOLECULAR MEDICINE | 2015年 / 21卷 / 11期

基金：

日本学术振兴会;

关键词：

MOUSE OOCYTES; HETEROCHROMATIN ESTABLISHMENT; PREIMPLANTATION DEVELOPMENT; ELECTRON-MICROSCOPE; MATERNAL NUCLEOLUS; EMBRYO DEVELOPMENT; PREPUBERTAL MOUSE; LIGHT-MICROSCOPE; RIBOSOMAL-RNA; ORGANIZATION;

D O I：

10.1016/j.molmed.2015.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1999, Tesarik and Greco reported that they could predict the developmental potential of human zygotes from a single static evaluation of their pronuclei. This was based on the distribution and number of specific nuclear organelles - the nucleoli. Recent studies in mice show that nucleoli play a key role in parental genome restructuring after fertilization, and that interfering with this process may lead to developmental failure. These studies thus support the Tesarik-Greco evaluation as a potentially useful method for selecting high-quality embryos in human assisted reproductive technologies. In this opinion article we discuss recent evidence linking nucleoli to parental genome reprogramming, and ask whether nucleoli can mirror or be used as representative markers of embryonic parameters such as chromosome content or DNA fragmentation.

引用

页码：663 / 672

页数：10

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