Crosstalk between maternal perinatal obesity and offspring dopaminergic circuitry

被引：0
|
作者：
Yasumoto, Yuki [1 ]
Horvath, Tamas L. [1 ]
机构：
[1] Yale Sch Med, Program Integrat Cell Signaling & Neurobiol Metab, Dept Comparat Med, New Haven, CT USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 07期
基金：
日本学术振兴会;
关键词：
HIGH-FAT DIET;
D O I：
10.1172/JCI138123
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The mechanism by which maternal obesity influences fetal brain development and behavior is not well understood. In this issue of the JCI, Lippert et al. showed that feeding maternal mice a high-fat diet (HFD) during lactation attenuated the activity of dopamine (DA) midbrain neurons and altered the DA-related behavioral phenotype seen in the offspring. The authors further suggested that the altered excitatory and inhibitory balance between D1 medium spiny neurons (MSN) and D2 MSN mediates this behavioral phenotype. These mechanisms may provide strategies for preventing the negative effects of maternal obesity on offspring development and adult health.
引用
收藏
页码：3416 / 3418
页数：3
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