Aurora A kinase activates YAP signaling in triple-negative breast cancer

被引：47
|
作者：
Chang, S-S [1 ,2 ]
Yamaguchi, H. [1 ]
Xia, W. [1 ]
Lim, S-O [1 ]
Khotskaya, Y. [3 ]
Wu, Y. [4 ]
Chang, W-C [5 ]
Liu, Q. [6 ,7 ]
Hung, M-C [1 ,2 ,5 ,8 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Unit 108, Houston, TX 77030 USA
[2] Univ Texas Houston, Grad Sch Biomed Sci Houston, Canc Biol Program, Houston, TX USA
[3] Univ Texas Houston, MD Anderson Canc Ctr, Sheikh Khalifa Bin Zayed Nahyan Inst Personalized, Houston, TX USA
[4] Univ Texas Houston, MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX USA
[5] China Med Univ, Ctr Mol Med, Taichung, Taiwan
[6] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Peoples R China
[7] Dalian Med Univ, First Affiliated Hosp, Collaborat Innovat Ctr Onco, Inst Canc Stem Cell, Dalian, Peoples R China
[8] Asia Univ, Dept Biotechnol, Taichung, Taiwan
来源：
ONCOGENE | 2017年 / 36卷 / 09期
基金：
美国国家卫生研究院;
关键词：
TO-MESENCHYMAL TRANSITION; HIPPO PATHWAY; CELL-MIGRATION; PROTEIN; PHOSPHORYLATION; KIBRA; COMPLEX; CHEMORESISTANCE; REGULATOR; TAZ;
D O I：
10.1038/onc.2016.292
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.
引用
收藏
页码：1265 / 1275
页数：11
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