Angiographic results of the first human experience with the Biolimus A9 drug-eluting stent for de novo coronary lesions

被引:50
|
作者
Costa, Ricardo A.
Lansky, Alexandra J. [1 ]
Abizaid, Alexandre
Mijeller, Ralph
Tsuchiya, Yoshihiro
Mori, Ken
Cristea, Ecaterina
Leon, Martin B.
Sousa, J. Eduardo
Schmidt, Thomas
Hauptmann, Karl E.
Grube, Eberhard
机构
[1] Cardiovasc Res Fdn, New York, NY USA
[2] Columbia Univ, Med Ctr, New York, NY USA
[3] Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil
[4] Siegburg Heart Ctr, Siegburg, Germany
[5] Bruderkrankenhaus Trier, Trier, Germany
来源
AMERICAN JOURNAL OF CARDIOLOGY | 2006年 / 98卷 / 04期
关键词
D O I
10.1016/j.amjcard.2006.02.051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This report describes angiographic findings of the first-in-human evaluation of the Biolimus A9 drug-eluting stent (Biolimus stent) in the treatment of noncomplex coronary lesions. In total, 120 patients with 122 de novo coronary lesions (2.75- to 4.00-mm vessels, <= 24-mm lesion length) were prospectively randomized in a 2:1 ratio to receive the Biolimus stent (n = 80, 82 lesions) or the control uncoated stent (n = 40). Baseline lesion and angiographic characteristics were similar between groups. At 6-month follow-up, late lumen loss was significantly decreased with the Biolimus stent in the stent (0.26 +/- 0.43 vs 0.74 +/- 0.45 mm, p < 0.001) and in the segment (0.14 +/- 0.45 vs 0.40 +/- 0.41 mm, p = 0.004). In-stent restenosis was 3.9% in the Biolimus stent group versus 7.7% in the control group (p = 0.40). There was no exaggerated hyperplasia at the proximal and/or distal edge of the stent. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:443 / 446
页数:4
相关论文
共 50 条
  • [1] First in-man experience of the biolimus A9 drug-eluting stent (MATRIX-Stent) in treatment of de novo coronary lesions: Results from the STEALTH-I trial
    Mehran, R
    Lansky, AJ
    Sousa, E
    Abizaid, A
    Costa, R
    Negoita, M
    Dunne-Tramis, AM
    Sikand, R
    Mogg, M
    Fahy, M
    Leon, MB
    Grube, E
    [J]. CIRCULATION, 2004, 110 (17) : 756 - 756
  • [2] BioMatrix® Biolimus A9®-eluting coronary stent:: a next-generation drug-eluting stent for coronary artery disease
    Grube, Eberhard
    Buellesfeld, Lutz
    [J]. EXPERT REVIEW OF MEDICAL DEVICES, 2006, 3 (06) : 731 - 741
  • [3] Biolimus A9 drug elating stent (MATRIX-Stent) in treatment of de novo coronary lesions: First-in-man experience (the STEALTH-I trial)
    Mehran, R
    Sousa, E
    Abizaid, A
    Abizaid, AS
    Fahy, M
    Negoita, M
    Leon, MB
    Grube, E
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (6A): : 69E - 69E
  • [4] Mid-term Angiographic Results of Drug-eluting Stent Implantations for De Novo Angulated Lesions: Comparison Among Drug-eluting Stents with Different Stent Designs
    Fuku, Yasushi
    Kadota, Kazushige
    Hersegawa, Daiji
    Shigemoto, Yoshikazu
    Habara, Seiji
    Tanaka, Hiroyuki
    Hosogi, Shingo
    Oka, Naoki
    Goto, Tsuyoshi
    Mitsudo, Kazuaki
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (13) : B45 - B45
  • [5] Clinical Studies with Sirolimus, Zotarolimus, Everolimus and Biolimus A9 Drug-Eluting Stent Systems
    Claessen, Bimmer E.
    Henriques, Jose P. S.
    Dangas, George D.
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (36) : 4012 - 4024
  • [6] High risk subgroups in patients treated with the BioMatrix™ Biolimus A9™-eluting coronary stent:: Results from the STEALTH (Stent Eluting A9 Biolimus™ Trial in Humans) trial
    Grube, E
    Abizaid, A
    Hauptmann, KE
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2005, 96 (7A): : 208H - 208H
  • [7] The AXXESS™ Self-Expanding Biolimus A9™ Eluting Stent System for coronary bifurcation lesions
    Dubois, Christophe L.
    Wijns, William
    [J]. EUROINTERVENTION, 2010, 6 : J130 - J134
  • [8] Use of the sirolimus drug-eluting stent for real world coronary lesions the Milan experience: Results of the first 400 lesions
    Spanos, V
    Stankovic, G
    Airoldi, F
    Montorfano, M
    Corvaja, N
    Liistro, F
    Chieffo, A
    Segura, M
    Tavano, D
    Di Mario, C
    Colombo, A
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (06) : 13A - 13A
  • [9] Is Drug-eluting Balloon Highly Favorable in De Novo Coronary Lesions
    Song, Yeo-Jeong
    Yoo, Sang-Yong
    Lee, Won-Kyung
    Bang, Woo-Dae
    Ha, Sang Jin
    Seo, Suk Min
    Cheong, Sangsig
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (16) : S21 - S21
  • [10] Comparison of a drug-eluting balloon first and then bare metal stent with a drug-eluting stent for treatment of de novo lesions: study protocol of a randomized controlled trial
    Sang-Don Park
    Chang-Hwan Yoon
    Il-Young Oh
    Jung-Won Suh
    Young-Suk Cho
    Tae-Jin Youn
    Dong-Ju Choi
    In-Ho Chae
    [J]. Trials, 14