Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates

被引：73
|
作者：
Sheng, Zi-Ke [1 ,2 ]
Hu, Fupin [1 ,2 ]
Wang, Weixia [1 ,2 ]
Guo, Qinglan [1 ,2 ]
Chen, Zhijun [1 ,2 ]
Xu, Xiaogang [1 ,2 ]
Zhu, Demei [1 ,2 ]
Wang, Minggui [1 ,2 ]
机构：
[1] Fudan Univ, Inst Antibiot, Huashan Hosp, Shanghai 200433, Peoples R China
[2] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 11期
基金：
中国国家自然科学基金;
关键词：
MULTIDRUG-RESISTANCE; SUSCEPTIBILITY; RAMR; EXPRESSION; MUTATIONS; ACRAB;
D O I：
10.1128/AAC.03808-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be explained by the present pathways. This study underscores the role of RamA in TNSKP and suggests the presence of novel tigecycline resistance mechanisms.
引用
收藏
页码：6982 / 6985
页数：4
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