α-Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358

被引：25
|
作者：
Shan, Wei-Guang [1 ]
Wu, Zhao-Ying [1 ]
Pang, Wei-Wei [1 ]
Ma, Lie-Feng [1 ]
Ying, You-Min [1 ]
Zhan, Zha-Jun [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2015年 / 12卷 / 11期
基金：
中国国家自然科学基金;
关键词：
HUPERZIA-SERRATA; METABOLITES; AUSTALIDES;
D O I：
10.1002/cbdv.201500027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D-NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on a-glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent a-glucosidase inhibitory activities than the positive control acarbose.
引用
收藏
页码：1718 / 1724
页数：7
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