Oxidative cyclization of amino alcohols catalyzed by a Cp*Ir complex. Synthesis of indoles, 1,2,3,4-tetrahydroquinolines, and 2,3,4,5-tetrahydro-1-benzazepine

被引：234

作者：

Fujita, K ^{[1
]}

Yamamoto, K

Yamaguchi, R

机构：

[1] Kyoto Univ, Grad Sch Global Environm Studies, Dept Nat Resources, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 16期

关键词：

D O I：

10.1021/ol026200s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new iridium-catalyzed oxidative cyclization of amino alcohols has been revealed. Indole derivatives are synthesized in good to excellent yields from 2-aminophenethyl alcohols by means of a [Cp(*)IrCl(2)](2)/K(2)CO(3) catalytic system. The present catalytic system is also effective for syntheses of 1,2,3,4-tetrahydroquinolines from 3-(2-aminophenyl)propanols and 2,3,4,5-tetrahydro-1-benzazepine from 4-(2-aminophenyl)butanol.

引用

页码：2691 / 2694

页数：4

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