Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.

被引：52

作者：

Clifford, LJ

Nair, MG ^{[1
]}

Rana, J

Dewitt, DL

机构：

[1] Michigan State Univ, Natl Food Safety & Toxicol Ctr 173, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA

[4] Alticor Corp, Ada, MI USA

[5] Michigan State Univ, Dept Biochem, E Lansing, MI 48824 USA

来源：

PHYTOMEDICINE | 2002年 / 9卷 / 03期

关键词：

Echinacea purpurea; alkamides; cyclooxygenase; enzyme; Aedes aegyptii; mosquitocidal;

D O I：

10.1078/0944-7113-00105

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 mug/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 mug/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 mug/ml.

引用

页码：249 / 253

页数：5

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