Therapeutic potential of the Nox1/4 inhibitor GKT137831 in scleroderma

被引：0
|
作者：
Dosoki, H. [1 ,2 ]
Taha, M. [3 ]
Schnittler, H. [3 ]
Szyndralewiez, C. [4 ]
Luger, T. A. [1 ]
Boehm, M. [1 ]
机构：
[1] Univ Munster, Dept Dermatol, Munster, Germany
[2] Univ Alexandria, Dept Bot & Microbiol, Alexandria, Egypt
[3] Univ Munster, Dept Anat, Munster, Germany
[4] Genkyotex SA, Geneva, Switzerland
来源：
EXPERIMENTAL DERMATOLOGY | 2017年 / 26卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
P084
引用
收藏
页码：E36 / E36
页数：1
相关论文
共 50 条
  • [1] Therapeutic potential of the Nox1/4 inhibitor GKT137831 in Systemic sclerosis
    Dosoki, H.
    Taha, M.
    Schnittler, H.
    Szyndralewiez, C.
    Luger, T. A.
    Boehm, M.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (10) : S308 - S308
  • [2] Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina
    Deliyanti, Devy
    Wilkinson-Berka, Jennifer L.
    JOURNAL OF NEUROINFLAMMATION, 2015, 12
  • [3] Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
    Jiang, Joy X.
    Chen, Xiangling
    Serizawa, Nobuko
    Szyndralewiez, Cedric
    Page, Patrick
    Schroeder, Katrin
    Brandes, Ralf P.
    Devaraj, Sridevi
    Toeroek, Natalie J.
    FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 (02) : 289 - 296
  • [4] Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina
    Devy Deliyanti
    Jennifer L. Wilkinson-Berka
    Journal of Neuroinflammation, 12
  • [5] Combined Nox1/4 inhibition with GKT137831 rescues established micro- and macrovascular diabetic complications
    Gray, S. P.
    Jha, J. C.
    Kennedy, K.
    Van Bommel, E.
    Chew, P.
    Szyndralewiez, C.
    Touyz, R.
    Schmidt, H.
    Cooper, M.
    Jandeleit-Dahm, K.
    DIABETOLOGIA, 2016, 59 : S31 - S31
  • [6] The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
    Green, David E.
    Murphy, Tamara C.
    Kang, Bum-Yong
    Kleinhenz, Jennifer M.
    Szyndralewiez, Cedric
    Page, Patrick
    Sutliff, Roy L.
    Hart, C. Michael
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 47 (05) : 718 - 726
  • [7] Setanaxib (GKT137831) Ameliorates Doxorubicin-Induced Cardiotoxicity by Inhibiting the NOX1/NOX4/Reactive Oxygen Species/MAPK Pathway
    Zheng, Hui
    Xu, Nannan
    Zhang, Zihao
    Wang, Fen
    Xiao, Jie
    Ji, Xiaoping
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [8] The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4
    Somanna, Naveen K.
    Valente, Anthony J.
    Krenz, Maike
    Fay, William P.
    Delafontaine, Patrice
    Chandrasekar, Bysani
    JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (05) : 1130 - 1141
  • [9] Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease
    Stephen P. Gray
    Jay C. Jha
    Kit Kennedy
    Erik van Bommel
    Phyllis Chew
    Cedric Szyndralewiez
    Rhian M. Touyz
    Harald H. H. W. Schmidt
    Mark E. Cooper
    Karin A. M. Jandeleit-Dahm
    Diabetologia, 2017, 60 : 927 - 937
  • [10] Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease
    Gray, Stephen P.
    Jha, Jay C.
    Kennedy, Kit
    van Bommel, Erik
    Chew, Phyllis
    Szyndralewiez, Cedric
    Touyz, Rhian M.
    Schmidt, Harald H. H. W.
    Cooper, Mark E.
    Jandeleit-Dahm, Karin A. M.
    DIABETOLOGIA, 2017, 60 (05) : 927 - 937
12345