Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study

被引：30

作者：

Kiuchi, Kuniaki ^{[1
,2
,3
]}

Kitamura, Soichiro ^{[1
,2
,4
]}

Taoka, Toshiaki ^{[5
]}

Yasuno, Fumihiko ^{[1
,2
]}

Tanimura, Masami ^{[6
]}

Matsuoka, Kiwamu ^{[1
,2
]}

Ikawa, Daisuke ^{[1
]}

Toritsuka, Michihiro ^{[1
]}

Hashimoto, Kazumichi ^{[1
]}

Makinodan, Manabu ^{[1
]}

Kosaka, Jun ^{[1
]}

Morikawa, Masayuki ^{[1
,7
]}

Kichikawa, Kimihiko ^{[5
]}

Kishimoto, Toshifumi ^{[1
,2
]}

机构：

[1] Nara Med Univ, Dept Psychiat, Kashihara, Nara 634, Japan

[2] Nara Med Univ, Med Ctr Dementia, Kashihara, Nara 634, Japan

[3] Sakai City Mental Hlth Ctr, Sakai, Osaka, Japan

[4] Natl Inst Radiol Sci, Mol Imaging Ctr, Chiba 260, Japan

[5] Nara Med Univ, Dept Radiol, Kashihara, Nara 634, Japan

[6] Doshisha Univ, Fac Psychol, Kyoto 602, Japan

[7] Mie Prefectural Mental Care Ctr, Tsu, Mie, Japan

来源：

PLOS ONE | 2014年 / 9卷 / 08期

关键词：

GLOBAL DETERIORATION SCALE; MEMORY IMPAIRMENT; HYPOTHETICAL MODEL; DYNAMIC BIOMARKERS; DEMENTIA; DECLINE; SCHIZOPHRENIA; ABNORMALITIES; ASSOCIATION; MARKERS;

D O I：

10.1371/journal.pone.0104007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.

引用

页数：7

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