Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers

被引:29
|
作者
Martinez-Baz, Ivan [1 ,2 ]
Trobajo-Sanmartin, Camino [3 ]
Arregui, Irati [3 ]
Navascues, Ana [3 ]
Adelantado, Marta [3 ]
Indurain, Juan [3 ]
Fresan, Ujue [1 ,2 ]
Ezpeleta, Carmen [3 ]
Castilla, Jesus [1 ,2 ]
机构
[1] Inst Salud Publ Navarra IdiSNA, Pamplona 31003, Spain
[2] CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
[3] Complejo Hosp Navarra IdiSNA, Clin Microbiol Dept, Pamplona 31008, Spain
关键词
SARS-CoV-2; COVID-19; influenza vaccination; health workers; pandemic;
D O I
10.3390/vaccines8040611
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vaccines may induce positive non-specific immune responses to other pathogens. This study aims to evaluate if influenza vaccination in the 2019-2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers. During the first SARS-CoV-2 epidemic wave in Spain, between March and May 2020, a cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected. Later in June, 8665 of them were tested for total antibodies in serum. A total of 890 (7.9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected. The adjusted odds ratio between 2019-2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same (1.07; 95% CI, 0.92-1.24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design). Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed an adjusted odds ratio of 0.86 (95% CI, 0.68-1.08). These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection. The development of specific vaccines against SARS-CoV-2 is urgent.
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页数:7
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