A Familial Case of Autoimmune Hepatitis

被引:7
|
作者
Yoshida, Osamu [1 ]
Abe, Masanori [1 ]
Furukawa, Shinya [1 ]
Murata, Yosuke [1 ]
Hamada, Maho [1 ]
Hiasa, Yoichi [1 ]
Matsuura, Bunzo [1 ]
Akbar, Fazle [1 ]
Michitaka, Kojiro [1 ]
Onji, Morikazu [1 ]
机构
[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, To On, Japan
关键词
autoimmune hepatitis; familial case; familial studies; environmental factors; SUSCEPTIBLE INDIVIDUALS; JAPANESE PATIENTS; A VIRUS; TYPE-1; TRIGGER;
D O I
10.2169/internalmedicine.48.1533
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Autoimmune hepatitis is a chronic liver disease, and both genetic background and environmental factors are related to its pathogenesis. Here, we report that out of five members of a family with similar human leukocyte antigen haplotypes, two developed autoimmune hepatitis, one was positive for antinuclear antibody, and the remaining two had no features of autoimmunity. The two patients with autoimmune hepatitis had a history of medication use, whereas the other family members did not. Our familial study suggests that in addition to genetic background, medication use and other environmental factors may be related to the onset of autoimmune hepatitis.
引用
收藏
页码:315 / 319
页数:5
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