Intracellular signaling for process elongation in cultured hepatic stellate cells on type I collagen gel

被引：0

作者：

Sato, M ^{[1
]}

Kojima, N ^{[1
]}

Miura, M ^{[1
]}

Imai, K ^{[1
]}

Senoo, H ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Anat, Akita 0108543, Japan

来源：

CELLS OF THE HEPATIC SINUSOID, VOL 7 | 1999年

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intracellular signaling, including protein kinase, PI 3-kinase, and small GTPases, following integrin-binding to extracellular matrix components, regulates F-actin and microtubule assembly in cultured HSCs, and has a crucial role in the induction and sustenance of the cellular processes. The difference in the responsiveness to signaling inhibitors of HSCs cultured on polystyrene surface and on type I collagen gel suggests that cell spreading and process elongation are mediated by the distinct signaling pathway(s), respectively.

引用

页码：32 / 33

页数：2

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