Modular Synthesis of α-Substituted Alkenyl Acetals by a Palladium-Catalyzed Suzuki Reaction of α-Haloalkenyl Acetals with Organoboranes

被引：6
|
作者：
Zhang, Li [1 ]
机构：
[1] Zhejiang Pharmaceut Coll, Sch Fundamental Sci, 666 Siming Rd, Ningbo 315500, Peoples R China
来源：
SYNLETT | 2021年 / 32卷 / 07期
关键词：
alkenyl acetals; palladium catalysis; Suzuki reaction; cross-coupling; arylboronic acids; arylation; CROSS-COUPLING REACTIONS; EFFICIENT; HYDROVINYLATION; PROTOCOL; ROUTE;
D O I：
10.1055/a-1322-3916
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular and straightforward synthetic strategy for the preparation of alpha-substituted alkenyl acetals has been developed. alpha-Haloalkenyl acetals react smoothly with (het)aryl boronic acids, aryl boronates, or B-alkyl-9-borabicyclo[3.3.1]nonanes through Pd-catalyzed Suzuki cross-coupling under mild conditions with good to high yields. This protocol features a broad substrate scope and good functional-group compatibility, and is easily scaled up.
引用
收藏
页码：723 / 727
页数：5
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