Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP3 prostanoid receptor

被引：38

作者：

Gallant, M ^{[1
]}

Carrière, MC ^{[1
]}

Chateauneuf, A ^{[1
]}

Denis, D ^{[1
]}

Gareau, Y ^{[1
]}

Godbout, C ^{[1
]}

Greig, G ^{[1
]}

Juteau, H ^{[1
]}

Lachance, N ^{[1
]}

Lacombe, P ^{[1
]}

Lamontagne, S ^{[1
]}

Metters, KM ^{[1
]}

Rochette, C ^{[1
]}

Ruel, R ^{[1
]}

Slipetz, D ^{[1
]}

Sawyer, N ^{[1
]}

Tremblay, N ^{[1
]}

Labelle, M ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Pointe Claire, PQ H9R 4P8, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00518-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent and selective ligands for the human EP3 prostanoid receptor are described. Biaryl compounds hearing a tethered ortho substituted acidic moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinity of key compounds on all eight human prostanoid receptors is reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2583 / 2586

页数：4

共 50 条

[1] Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor
Juteau, HN
Gareau, Y
Labelle, M
Sturino, CF
Sawyer, N
Tremblay, N
Lamontagne, S
Carrière, MC
Denis, D
Metters, KM
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (08) : 1977 - 1984
[2] Structure activity relationship of triaryl and biaryl carboxylic acid and acylsulfonamide analogs on the human EP3 Prostanoid receptor.
Gallant, M
Belley, M
Carrière, MC
Gareau, Y
Juteau, H
Lachance, N
Lacombe, P
Lamontagne, S
Metters, KM
Sawyer, N
Slipetz, D
Tremblay, NM
Labelle, M
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U674 - U674
[3] Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor
Gallant, M
Belley, M
Carrière, MC
Chateauneuf, A
Denis, D
Lachance, N
Lamontagne, S
Metters, KM
Sawyer, N
Slipetz, D
Truchon, JF
Labelle, M
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (21) : 3813 - 3816
[4] Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry
Juteau, H
Gareau, Y
Labelle, M
Lamontagne, S
Tremblay, N
Carrière, MC
Sawyer, N
Denis, D
Metters, KM
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (05) : 747 - 749
[5] Effect of prostaglandin analogues on IOP in prostanoid EP1 and EP3 receptor deficient mice
Ota, T
Aihara, M
Narumiya, S
Araie, M
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
[6] Crystal structure of the endogenous agonist-bound prostanoid receptor EP3
Kazushi Morimoto
Ryoji Suno
Yunhong Hotta
Keitaro Yamashita
Kunio Hirata
Masaki Yamamoto
Shuh Narumiya
So Iwata
Takuya Kobayashi
Nature Chemical Biology, 2019, 15 : 8 - 10
[7] The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice
Ota, Takashi
Aihara, Makoto
Saeki, Tadashiro
Narumiya, Shuh
Araie, Makoto
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (08) : 3395 - 3399
[8] Crystal structure of the endogenous agonist-bound prostanoid receptor EP3
Morimoto, Kazushi
Suno, Ryoji
Hotta, Yunhong
Yamashita, Keitaro
Hirata, Kunio
Yamamoto, Masaki
Narumiya, Shuh
Iwata, So
Kobayashi, Takuya
NATURE CHEMICAL BIOLOGY, 2019, 15 (01) : 8 - +
[9] OCULAR HYPOTENSIVE ACTIVITY OF SULPROSTONE, A POTENT AND SELECTIVE PROSTANOID EP1/EP3 RECEPTOR AGONIST
WATERBURY, LD
EGLEN, RM
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1990, 47 (02) : 150 - 150
[10] THE STRUCTURE OF THE EP3 RECEPTOR GENE
TARNG, JL
BREYER, RM
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 763 - 763

← 1 2 3 4 5 →