Poly(lactic-co-glycolic acid) Nanoparticles as Delivery Systems for the Improved Administration of Radiotherapeutic Anticancer Agents

被引：9
|
作者：
Ambrogio, Michael W. [1 ]
Toro-Gonzale, Miguel [1 ]
Keever, Tamara J. [1 ]
McKnight, Timothy E. [1 ]
Davern, Sandra M. [1 ]
机构：
[1] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA
来源：
ACS APPLIED NANO MATERIALS | 2020年 / 3卷 / 11期
关键词：
nanoparticles; drug delivery; targeted alpha-therapy; poly(lactic-co-glycolic acid); radionuclides;
D O I：
10.1021/acsanm.0c02350
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This letter reports the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) as delivery systems that could potentially encapsulate and improve the administration of radiotherapeutic anticancer agents. Different metal ions (Ba, Gd, and Ce) were used as surrogates of alpha-emitting radionuclides (Ra-223, Ac-225, and Th-227), and their encapsulation within the PLGA NPs (D-h < 300 nm) was evaluated. The initial concentration of metal ions, the metal salt (nitrate vs chloride), and the presence of chelators influenced the concentration of surrogate ions within the PLGA NPs. This letter shows the potential of PLGA NPs to encapsulate radionuclides, particularly alpha-emitters, for their application in nuclear medicine.
引用
收藏
页码：10565 / 10570
页数：6
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