Holding it together: Nanoparticle stabilization of LASV trimer

被引：2
|
作者：
Gunn, Bronwyn M. [1 ]
机构：
[1] Washington State Univ, Paul G Allen Sch Global Hlth, Pullman, WA 99164 USA
来源：
CELL HOST & MICROBE | 2022年 / 30卷 / 12期
关键词：
PROTECTS NONHUMAN-PRIMATES;
D O I：
10.1016/j.chom.2022.11.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The development of Lassa virus (LASV) vaccines has been challenging due to the instability of recombinant immunogens. In this issue of Cell Host & Microbe, Brouwer et al. use a two-component nanoparticle strategy that enables stable trimeric presentation of the LASV glycoprotein complex (GPC) and induction of broadly neutralizing antibodies.
引用
收藏
页码：1660 / 1661
页数：2
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