SCF-β-TrCP E3 Ubiquitin Ligase-Mediated Proteolysis Of EZH2 Regulates H3K27 Trimethylation Activity In Germinal Center-Derived B-Cell Lymphomas

被引:0
|
作者
Sahasrabuddhe, Anagh A.
Chen, Xiaofei
Chung, Fuzon
Velusamy, Thirunavukkarasu
Lim, Megan S.
Elenitoba-Johnson, Kojo S. J.
机构
关键词
D O I
10.1182/blood.V122.21.244.244
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
244
引用
收藏
页数:2
相关论文
共 14 条
  • [1] Oncogenic Y641 mutations in EZH2 prevent Jak2/β-Trcp-mediated degradation in germinal center-derived B-cell lymphomas
    Sahasrabuddhe, A.
    Chen, X.
    Chung, F.
    Velusamy, T.
    Lim, M. S.
    Elenitoba-Johnson, K. S. J.
    EUROPEAN JOURNAL OF CANCER, 2016, 54 : S45 - S45
  • [2] Mutation of EZH2 A677 in human B-cell lymphoma promotes hyper-trimethylation of H3K27
    McCabe, Michael T.
    Graves, Alan P.
    Ganji, Gopinath
    Ott, Heidi
    Diaz, Elsie
    Haisey, Wendy S.
    Jiang, Yong
    Smitheman, Kimberly N.
    Pappalardi, Melissa B.
    Allen, Kimberly E.
    Chen, Stephanie
    Della-Pietra, Anthony
    Dul, Edward
    Hughes, Ashley M.
    Thrall, Sara H.
    Tummino, Peter J.
    Kruger, Ryan G.
    Brandt, Martin
    Schwartz, Benjamin
    Verma, Sharad K.
    Creasy, Caretha L.
    CANCER RESEARCH, 2012, 72
  • [3] A Novel Non-Canonical Phosphodegron Regulates EZH2 Proteasomal Degradation and H3K27 Trimethylation Activity in Hematopoietic Malignancies
    Sahasrabuddhe, Anagh A.
    Chen, Xiaofei
    Velusamy, Thirunavukkarasu
    Chung, Fuzon
    Lim, Megan S.
    Elenitoba-Johnson, Kojo S. J.
    BLOOD, 2014, 124 (21)
  • [4] PROGNOSTIC IMPACT OF EZH2 EXPRESSION, H3K27 TRIMETHYLATION AND DNA METHYLATION IN DIFFUSE LARGE B CELL LYMPHOMA
    Lin, S.
    Tsai, C.
    Chuang, S.
    Chou, W.
    HAEMATOLOGICA, 2013, 98 : 127 - 127
  • [5] EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma
    Xie, Shao
    Wei, Fan
    Sun, Yi-ming
    Gao, Ying-lei
    Pan, Lu-lu
    Tan, Min-jia
    Wang, Shu-dong
    Ding, Jian
    Chen, Yi
    HAEMATOLOGICA, 2020, 105 (04) : 1021 - 1031
  • [6] Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation
    Zhou, Zheng
    Gao, Juehua
    Popovic, Relja
    Wolniak, Kristy
    Parimi, Vamsi
    Winter, Jane N.
    Licht, Jonathan D.
    Chen, Yi-Hua
    LEUKEMIA & LYMPHOMA, 2015, 56 (10) : 2895 - 2901
  • [7] LncRNA HOTAIR regulates the expression of E-cadherin to affect nasopharyngeal carcinoma progression by recruiting histone methylase EZH2 to mediate H3K27 trimethylation
    Yang, Feng-Lian
    Wei, Yu-Xia
    Liao, Bi-Yun
    Wei, Gui-Jiang
    Qin, Hai-Mei
    Pang, Xiao-Xia
    Wang, Jun-Li
    GENOMICS, 2021, 113 (04) : 2276 - 2289
  • [8] Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    McCabe, Michael T.
    Graves, Alan P.
    Ganji, Gopinath
    Diaz, Elsie
    Halsey, Wendy S.
    Jiang, Yong
    Smitheman, Kimberly N.
    Ott, Heidi M.
    Pappalardi, Melissa B.
    Allen, Kimberly E.
    Chen, Stephanie B.
    Della Pietra, Anthony, III
    Dul, Edward
    Hughes, Ashley M.
    Gilbert, Seth A.
    Thrall, Sara H.
    Tummino, Peter J.
    Kruger, Ryan G.
    Brandt, Martin
    Schwartz, Benjamin
    Creasy, Caretha L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (08) : 2989 - 2994
  • [9] Strong Expression of Enhancer of Zest Homolog 2 (EZH2) and Accumulation of Trimethylated H3K27 in Diffuse Large B-Cell Lymphoma (DLBCL) Irrespective of Germinal Center B (GCB) or Activated B Cell (ABC) Type and EZH2 Y641 Mutation
    Zhou, Z.
    Gao, J.
    Wolniak, K.
    Parimi, V.
    Winter, J. N.
    Licht, J. D.
    Chen, Y-H
    LABORATORY INVESTIGATION, 2014, 94 : 389A - 389A
  • [10] Strong Expression of Enhancer of Zest Homolog 2 (EZH2) and Accumulation of Trimethylated H3K27 in Diffuse Large B-Cell Lymphoma (DLBCL) Irrespective of Germinal Center B (GCB) or Activated B Cell (ABC) Type and EZH2 Y641 Mutation
    Zhou, Z.
    Gao, J.
    Wolniak, K.
    Parimi, V.
    Winter, J. N.
    Licht, J. D.
    Chen, Y-H
    MODERN PATHOLOGY, 2014, 27 : 389A - 389A