Survival of rat cerebrocortical neurons after rickettsial infection

被引：8

作者：

Bohacsova, Monika ^{[1
]}

Filipcik, Peter ^{[2
]}

Opattova, Alena ^{[2
]}

Valarikova, Jana ^{[1
]}

Diaz, Marco Quevedo ^{[1
]}

Skultety, Ludovit ^{[1
]}

Novak, Michal ^{[2
]}

Sekeyova, Zuzana ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Virol, Bratislava 84505, Slovakia

[2] Slovak Acad Sci, Inst Neuroimmunol, Bratislava 84505, Slovakia

来源：

MICROBES AND INFECTION | 2015年 / 17卷 / 11-12期

关键词：

Rickettsiae; Cerebrocortical neurons; Survival; ATP; Immunofluorescence; MEDITERRANEAN SPOTTED-FEVER; MURINE TYPHUS; TAU-PROTEIN; YOLK-SAC; EXPRESSION; PROWAZEKII; HELVETICA; SLOVACA; LYMPHADENOPATHY; ENCEPHALITIS;

D O I：

10.1016/j.micinf.2015.09.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinvasive microorganisms are suspected to play an important role in the etiopathogenesis of neurological diseases. However, direct evidence for the pathogenic function is still missing. The main aim of this study was to investigate biochemical and morphological changes that may occur as a result of an in vitro infection of rat cerebrocortical neurons by selected members of the genus Rickettsia. Our results showed that survival of the neurons is significantly reduced after the infection. Intracellular level of ATP is gradually decreased and inversely correlates with the load of rickettsiae. Immunofluorescence revealed that rickettsiae can enter the neurons and are localized in perinuclear space and also in neuronal processes. Data obtained in this study correspond to the idea of possible involvement of rickettsiae in the etiopathogenesis of various neuropathies. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：845 / 849

页数：5

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