Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study

被引：5

作者：

Vaut, Lukas ^{[1
,2
]}

Jensen, Kristian E. ^{[1
,2
]}

Tosello, Guido ^{[3
]}

Khosla, Ajit ^{[4
]}

Furukawa, Hidemitsu ^{[4
]}

Boisen, Anja ^{[1
,2
]}

机构：

[1] Tech Univ Denmark, Danish Natl Res Fdn, DK-2800 Lyngby, Denmark

[2] Tech Univ Denmark, Villum Fdn, Ctr Intelligent Drug Delivery & Sensing Using Mic, Dept Hlth Technol, DK-2800 Lyngby, Denmark

[3] Tech Univ Denmark, Dept Mech Engn, DK-2800 Lyngby, Denmark

[4] Yamagata Univ, Grad Sch Sci & Engn, Dept Mech Syst Engn, Yonezawa, Yamagata 9928510, Japan

来源：

JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2019年 / 166卷 / 09期

基金：

新加坡国家研究基金会; 日本科学技术振兴机构; 日本学术振兴会;

关键词：

Delivery systems - Fabrication method - Fabrication process - Feasibility studies - Micro-stereo lithography - Oral drug delivery - Resolution tests - State of the art;

D O I：

10.1149/2.0421909jes

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300 mu m have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods. In this feasibility study, state-of-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process. (C) The Author(s) 2019. Published by ECS.

引用

页码：B3257 / B3263

页数：7