Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer

被引:209
|
作者
Mochiki, E
Kuwano, H
Katoh, H
Asao, T
Oriuchi, N
Endo, K
机构
[1] Gunma Univ, Fac Med, Dept Surg 1, Maebashi, Gumma 3718511, Japan
[2] Gunma Univ, Fac Med, Dept Nucl Med, Maebashi, Gumma 3718511, Japan
关键词
D O I
10.1007/s00268-003-7191-5
中图分类号
R61 [外科手术学];
学科分类号
摘要
Positron emission tomography (PET) with F-18-2-deoxy-2-fluoro-D-glucose (FDG) has been investigated as a means of detecting certain primary tumors and their metastatic disease in recent years. The aim of this study was to compare the performance of FDG-PET and operative assessment with formal pathologic staging. Altogether, 85 patients had undergone surgical treatment for gastric cancer with curative intent, with FDG-PET preoperatively. The results using FDG-PET were compared with those using computed tomography (CT); they were also correlated with the pathologic findings. For quantitative analysis, the regional tumor uptake was measured by the standard uptake value (SUV) using a region of interest technique. Using FDG-PET, the primary tumor was visualized in 75.2% of patients. A comparison of the FDG uptake and the clinicopathologic findings showed that there was a significant association between FDG uptake and the depth of invasion, the size of the tumor, and lymph node metastasis. FDG-PET scans had less accuracy for diagnosing locoregional lymph nodes than CT because of a significant lack of sensitivity (23.3% vs. 65.0%). The survival rate for patients with high FDG uptake (SUV > 4) was significantly lower than that for those with low FDG uptake (SUV < 4) (p < 0.05). FDG-PET was successful in detecting the primary gastric cancer lesion but not for finding early-stage gastric cancers. Detection of nodal metastasis also was not possible by FDG-PET. However, FDG-PET appears to provide important additional information concerning the aggressiveness of the tumor and the prognosis in patients with gastric cancer.
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页码:247 / 253
页数:7
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