Platelet reactivity in spontaneously diabetic rats is independent from blood glucose and insulin levels

被引：9
|
作者：
Taka, T
Ono, H
Sasaki, Y
Seki, JJ
Yamamoto, J [1 ]
机构：
[1] Kobe Gakuin Univ, Fac Nutr, Physiol Lab, Nishi Ku, Kobe, Hyogo 6512180, Japan
[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan
[3] Natl Cardiovasc Ctr, Res Inst, Dept Bioengn, Osaka, Japan
来源：
PLATELETS | 2002年 / 13卷 / 5-6期
关键词：
D O I：
10.1080/0953371027000-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Diabetes is associated with thrombotic disorders. Chemically induced and spontaneously induced diabetic animals and various in vitro tests have been used to reveal the prothrombotic state of diabetic patients. However, the results are not consistent. In the present study, platelet reactivity of spontaneously diabetic Goto-Kakizaki rats in vivo and in vitro was evaluated by laser-induced and shear-induced thrombosis models, which are physiologically relevant to thrombosis. Both results showed platelet hyperreactivity.
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页码：313 / 316
页数：4
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