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Limited Hepatitis B Virus Replication Space in the Chronically Hepatitis C Virus-Infected Liver

被引：27
|
作者：
Wieland, S. F. [1 ]
Asabe, S. [1 ]
Engle, R. E. [2 ]
Purcell, R. H. [2 ]
Chisari, F. V. [1 ]
机构：
[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
[2] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF VIROLOGY | 2014年 / 88卷 / 09期
关键词：
TRANSGENIC MICE; GENOMIC ANALYSIS; VIRAL CLEARANCE; HOST RESPONSE; HUH-7; CELLS; CHIMPANZEES; INTERFERON; EXPRESSION; COINFECTION; DISEASE;
D O I：
10.1128/JVI.03553-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.
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页码：5184 / 5188
页数：5
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