SYNTHESIS OF 2-(2-(HYDROXYMETHYL)PHENYL)ETHANOL DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

被引：7
|
作者：
Manivel, P. [1 ,2 ]
Khan, F. Nawaz [1 ]
机构：
[1] VIT Univ, Sch Sci & Humanities, Div Organ Chem, Vellore, Tamil Nadu, India
[2] Syngene Int Ltd, Bangalore, Karnataka, India
来源：
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2009年 / 54卷 / 02期
关键词：
Isocoumarin; sodium borohydride; diol; antimicrobial properties; ACID; ISOCOUMARINS; ALLYLATION; ALKYNES;
D O I：
10.4067/S0717-97072009000200019
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of 3-substituted isocoumarins (1a-h) with excess of sodium borohydride in methanol gave the corresponding 2-(2-(hydoxymethyl)phenyl)ethanol derivatives (2a-h). Antimicrobial activities of synthesized compounds were measured, using Gram-negative (Escherichia coli. Salmonella typhi, Proteus mirabilis) and Gram-positive bacteria (Bacillus cereus, Staphylococcus aureus).
引用
收藏
页码：180 / 182
页数：3
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