Preparative Chromatography Technique in the Removal of Isostructural Genotoxic Impurity in Rizatriptan: Use of Physicochemical Descriptors of Solute and Adsorbent

被引：12

作者：

Maddula, Srinivasula Reddy ^{[1
]}

Kharkar, Manoj ^{[1
]}

Manudhane, Kushal ^{[1
]}

Kale, Sandeep ^{[1
]}

Bhori, Abijar ^{[2
]}

Lali, Arvind ^{[2
]}

Dubey, P. K. ^{[3
]}

Sarma, K. R. Janardana ^{[1
]}

Bhattacharya, Apurba ^{[1
]}

Bandichhor, Rakeshwar ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Ctr Excellence Res & Dev, Integrated Prod Dev, Survey 42 45 46 & 54 Bachupally, Qutubullapur 500072, Andhra Pradesh, India

[2] Inst Chem Technol, Bioproc Lab, Dept Chem Engn, Bombay 400019, Maharashtra, India

[3] JNTU, Coll Engn, Hyderabad 500072, Andhra Pradesh, India

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2009年 / 13卷 / 04期

关键词：

PHASE LIQUID-CHROMATOGRAPHY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IONIZABLE COMPOUNDS; PROTEIN RETENTION; IONIC-STRENGTH; MOBILE PHASES; PREDICTION; BEHAVIOR; PH; ADSORPTION;

D O I：

10.1021/op9000093

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The development of preparative negative hydrophobic interaction chromatographic technique based on molecular structural descriptors and physicochemical descriptors e.g. the dissociation constant (pK(a)), partition coefficient (logP), and distribution coefficient (logD) for removal of a structurally related genotoxic dimer impurity from rizatriptan bulk drug is presented.

引用

页码：683 / 689

页数：7