TET Proteins and 5-Methylcytosine Oxidation in the Immune System

被引：28

作者：

Tsagaratou, Ageliki ^{[1
]}

Rao, Anjana ^{[1
,2
,3
]}

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[3] Sanford Consortium Regenerat Med, La Jolla, CA 92037 USA

来源：

IMMUNITY AND TOLERANCE | 2013年 / 78卷

关键词：

ACUTE MYELOID-LEUKEMIA; GENOME-WIDE ANALYSIS; DNA METHYLATION; EPIGENETIC DYNAMICS; EPIGENOMIC ANALYSIS; LINEAGE COMMITMENT; CXXC DOMAIN; SRA DOMAIN; 5-HYDROXYMETHYLCYTOSINE; DEMETHYLATION;

D O I：

10.1101/sqb.2013.78.020248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation in the form of 5-methylcytosine (SmC) is essential for normal development in mammals and influences a variety of biological processes, including transcriptional regulation, imprinting, and the maintenance of getumlic stability. The recent discovery of TET proteins, which oxidize 5mC to 5-hydroxymethylcytosine, 5-formylcytosine. and 5-carboxylcytosine, has changed our understanding of the process of DNA demethylat ion. Here, we summarize our current knowledge of the roles of DNA methylation and TET proteins in cell differentiation and function. The intensive research on this subject has so far focused primarily on embryonic stem (ES) cells and neurons. In addition, we summarize what is known about DNA methylation in T-cell function.

引用

页码：1 / 10

页数：10

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