Catalytic asymmetric transfer hydrogenation: an industrial perspective

被引：0
|
作者：
Cotarca, Livius [1 ]
Verzini, Massimo [1 ]
Volpicelli, Raffaella [1 ]
机构：
[1] ZaCh Syst SpA, I-36045 Lonigo, VI, Italy
来源：
CHIMICA OGGI-CHEMISTRY TODAY | 2014年 / 32卷 / 05期
关键词：
catalytic asymmetric transfer hydrogenation; ATH; industrial applications; ketones; imines; reductive amination; ENANTIOSELECTIVE SYNTHESIS; RUTHENIUM(II) COMPLEXES; PRACTICAL SYNTHESIS; KETONES; REDUCTION; EFFICIENT; LIGANDS; GREENER;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Asymmetric transfer hydrogenation (ATH) of ketones and imines has emerged as a powerful alternative to asymmetric hydrogenation (AH) for the production of optically active alcohols and amines. The Noyori-type catalysts are still the most widely applied for industrial manufacture, because of their modularity, efficiency, stability and cost-effectiveness. The present review presents an account of recent examples of ATH reactions reported for the production of pharmaceuticals and agrochemicals. Particular attention will be given to a case study on the ATH process developed as a key step in the synthesis of the Active Pharmaceutical Ingredient (API) Dorzolamide HCl.
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页码：36 / 41
页数：6
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