Type 1 diabetes mellitus caused by treatment with interferon-β

被引：17

作者：

Kado, S ^{[1
]}

Miyamoto, J ^{[1
]}

Komatsu, N ^{[1
]}

Iwaki, Y ^{[1
]}

Ozaki, H ^{[1
]}

Taguchi, H ^{[1
]}

Kure, M ^{[1
]}

Sarashina, G ^{[1
]}

Watanabe, T ^{[1
]}

Katsura, Y ^{[1
]}

Nemoto, Y ^{[1
]}

Noritake, M ^{[1
]}

Matsuoka, T ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Internal Med 5, Inashiki, Ibaragi 3000395, Japan

来源：

INTERNAL MEDICINE | 2000年 / 39卷 / 02期

关键词：

GAD antibody; chronic hepatitis; hepatitis C virus; human leukocyte antigen;

D O I：

10.2169/internalmedicine.39.146

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 57-year-old man was referred to our outpatient clinic after interferon-beta (IFN-beta) treatment for 7 weeks. While IFN-beta therapy was continued in our outpatient clinic, his blood glucose level increased gradually, and he was admitted to our hospital for hyperglycemia. The patient was prescribed a 1,600-kcal diet and intensive insulin therapy was performed. GAD antibody became positive 15 months after the start of IFN therapy, and disappeared 27 months after the start of IFN therapy. Insulin secretion was depleted and the patient had HLA-DR4, B54, and DRB1*0405, This appears to be a case of type 1 diabetes mellitus induced by administration of IFN-beta alone.

引用

页码：146 / 149

页数：4

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