A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice

被引:9
|
作者
Ahn, Seunghyun [1 ]
Lee, Jung Yeon [1 ]
Choi, Sang Mi [1 ]
Shin, Yujeong [1 ]
Park, Seyeon [1 ]
机构
[1] Dongduk Womens Univ, Dept Appl Chem, Seoul 02748, South Korea
基金
新加坡国家研究基金会;
关键词
synergistic effect; transcriptome analysis; functional gene clustering; skin development; hair cycle-related gene; DERMAL PAPILLA; FOLLICLE GROWTH; CELL NUMBER; ACTIVATION; STEVIOSIDE; SIZE;
D O I
10.3390/pharmaceutics12121234
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Oral finasteride and topical minoxidil are single components approved by the US FDA for treating hair loss. Some other compounds originating from natural products are also traditionally used for promoting hair growth. In this study, observations of treated keratinocyte cells were used to demonstrate that tocopherol acetate, L-menthol, and stevioside exert an effect on cell regeneration. Furthermore, these were topically applied to the shaved skin of C57BL/6 mice to observe their effects on hair growth. A mixture of tocopherol acetate, L-menthol, and stevioside showed the highest potential for promoting hair growth in vivo. In in vivo experiments, the mixture of tocopherol acetate, L-menthol, and stevioside was more effective than tocopherol acetate or L-menthol alone in promoting hair growth. The transcriptome analysis of skin from the dorsal side of a mouse treated with tocopherol acetate or L-menthol versus vehicle revealed key changes in keratin, keratin-associated protein, forkhead box, sonic hedgehog, fibroblast growth factor 10, desmoglein 4, deoxyribonuclease 1-like 2, and cadherin 3, known to play roles in promoting hair growth.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 50 条
  • [1] Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice
    Nagai, Noriaki
    Iwai, Yoshie
    Sakamoto, Akane
    Otake, Hiroko
    Oaku, Yoshihiro
    Abe, Akinari
    Nagahama, Tohru
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 : 7921 - 7931
  • [2] Fructus panax ginseng extract promotes hair regeneration in C57BL/6 mice
    Park, Soojin
    Shin, Weon-Sun
    Ho, Jinnyoung
    JOURNAL OF ETHNOPHARMACOLOGY, 2011, 138 (02) : 340 - 344
  • [3] Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice
    Oaku, Yoshihiro
    Abe, Akinari
    Sasano, Yohei
    Sasaki, Fuka
    Kubota, Chika
    Yamamoto, Naoki
    Nagahama, Tohru
    Nagai, Noriaki
    PHARMACEUTICS, 2022, 14 (05)
  • [4] Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice
    Kim, Young Eun
    Choi, Hyung Chul
    Nam, Gaewon
    Choi, Bu Young
    JOURNAL OF COSMETIC DERMATOLOGY, 2019, 18 (01) : 414 - 421
  • [5] Methionine Dependence of Hair Maintenance in C57BL/6 Mice
    Kubota, Yutaro
    Varshney, Nundini
    Kobayashi, Keita
    Tsunoda, Takuya
    Hoffman, Robert M.
    IN VIVO, 2024, 38 (03): : 1199 - 1202
  • [6] Fluvastatin Influences Hair Color in C57Bl/6 Mice
    Galus, Ryszard
    Wlodarski, Krzysztof
    Malejczyk, Jacek
    Jozwiak, Jaroslaw
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (07): : 14333 - 14345
  • [7] Hair growth-promoting effects of lavender oil in C57BL/6 mice
    Lee B.H.
    Lee J.S.
    Kim Y.C.
    Toxicological Research, 2016, 32 (2) : 103 - 108
  • [8] Evaluation of Herbal Hair Lotion loaded with Rosemary for Possible Hair Growth in C57BL/6 Mice
    Begum, Asia
    Sandhya, S.
    Kumar, Anoop N.
    Ali, Syed S.
    ADVANCED BIOMEDICAL RESEARCH, 2023, 12 (01): : 60
  • [9] A comparison of the behavior of C57BL/6 and C57BL/10 mice
    Deacon, R. M. J.
    Thomas, C. L.
    Rawlins, J. N. P.
    Morley, B. J.
    BEHAVIOURAL BRAIN RESEARCH, 2007, 179 (02) : 239 - 247
  • [10] Autoimmune hair loss induced by alloantigen in C57BL/6 mice
    Zong, ZP
    Matsui, S
    Li, AL
    Katsuda, S
    Yamaguchi, N
    CELL STRUCTURE AND FUNCTION, 2003, 28 (01) : 97 - 104