Emergence of chronic Lyme arthritis: Putting the breaks on CD28 costimulation

被引：1
|
作者：
Iliopoulou, Bettina Panagiota [1 ]
Huber, Brigitte T. [1 ]
机构：
[1] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA
来源：
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2009年 / 31卷 / 02期
关键词：
CD28; Lyme arthritis; murine models; immunoregulation; BORRELIA-BURGDORFERI LIPOPROTEINS; SURFACE PROTEIN-A; CELL-MEDIATED-IMMUNITY; T-CELLS; PROTECTIVE ANTIBODIES; TOXOPLASMA-GONDII; IL-10; PRODUCTION; SYNOVIAL-FLUID; CD40; LIGAND; IFN-GAMMA;
D O I：
10.1080/08923970802391459
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lyme disease is a debilitating infection that is caused upon a bite of Borrelia burgdorferi (Bb)-infected ticks. One of the most prominent clinical manifestations is the development of chronic Lyme arthritis. Months after Bb infection, similar to 60% of untreated Lyme patients experience intermittent arthritic attacks that may last for years. The use of the CD28(-/-) mouse in Bb infection has helped to shed light into the mechanisms that govern this inflammatory process, which seems to be tightly regulated. In this current review, the effect of immunoregulation, as well as CD28 deficiency in the development of chronic Lyme arthritis is discussed.
引用
收藏
页码：180 / 185
页数：6
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