Amygdala functional connectivity in major depression - disentangling markers of pathology, risk and resilience

被引:23
|
作者
Wackerhagen, Carolin [1 ]
Veer, Ilya M. [1 ]
Erk, Susanne [1 ]
Mohnke, Sebastian [1 ]
Lett, Tristram A. [1 ,2 ]
Wuestenberg, Torsten [1 ]
Romanczuk-Seiferth, Nina Y. [1 ]
Schwarz, Kristina [3 ]
Schweiger, Janina, I [3 ]
Tost, Heike [3 ]
Meyer-Lindenberg, Andreas [3 ]
Heinz, Andreas [1 ]
Walter, Henrik [1 ]
机构
[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Mitte, Berlin, Germany
[2] Charite Univ Med Berlin, Dept Neurol Expt Neurol, Campus Mitte, Berlin, Germany
[3] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany
关键词
Amygdala; faces; familial risk; functional connectivity; intermediate phenotype; major depressive disorder; pathology; resilience; risk; INTRINSIC CONNECTIVITY; GENETIC-VARIATION; METAANALYSIS; DISORDER; BRAIN; MODEL; ACTIVATION; NETWORK; STATE; VULNERABILITY;
D O I
10.1017/S0033291719002885
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Limbic-cortical imbalance is an established model for the neurobiology of major depressive disorder (MDD), but imaging genetics studies have been contradicting regarding potential risk and resilience mechanisms. Here, we re-assessed previously reported limbic-cortical alterations between MDD relatives and controls in combination with a newly acquired sample of MDD patients and controls, to disentangle pathology, risk, and resilience. Methods. We analyzed functional magnetic resonance imaging data and negative affectivity (NA) of MDD patients (n = 48), unaffected first-degree relatives of MDD patients (n = 49) and controls (n = 109) who performed a faces matching task. Brain response and task-dependent amygdala functional connectivity (FC) were compared between groups and assessed for associations with NA. Results. Groups did not differ in task-related brain activation but activation in the superior frontal gyrus (SFG) was inversely correlated with NA in patients and controls. Pathology was associated with task-independent decreases of amygdala FC with regions of the default mode network (DMN) and decreased amygdala FC with the medial frontal gyrus during faces matching, potentially reflecting a task-independent DMN predominance and a limbic-cortical disintegration during faces processing in MDD. Risk was associated with task-independent decreases of amygdala-FC with fronto-parietal regions and reduced faces-associated amygdala-fusiform gyrus FC. Resilience corresponded to task-independent increases in amygdala FC with the perigenual anterior cingulate cortex (pgACC) and increased FC between amygdala, pgACC, and SFG during faces matching. Conclusion. Our results encourage a refinement of the limbic-cortical imbalance model of depression. The validity of proposed risk and resilience markers needs to be tested in prospective studies. Further limitations are discussed.
引用
收藏
页码:2740 / 2750
页数:11
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