Low- and High-Frequency Oscillations Reveal Distinct Absence Seizure Networks

被引:55
|
作者
Tenney, Jeffrey R. [1 ,2 ]
Fujiwara, Hisako [1 ]
Horn, Paul S. [1 ,3 ]
Vannest, Jennifer [1 ,2 ]
Xiang, Jing [1 ,2 ]
Glauser, Tracy A. [1 ]
Rose, Douglas F. [1 ]
机构
[1] Univ Cincinnati, Div Neurol, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[2] Univ Cincinnati, Pediat Neuroimaging Res Consortium, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[3] Univ Cincinnati, Dept Math Sci, Cincinnati, OH USA
关键词
IDIOPATHIC GENERALIZED EPILEPSY; SPIKE-WAVE DISCHARGES; WAG/RIJ RATS; EEG-FMRI; FUNCTIONAL CONNECTIVITY; STATUS EPILEPTICUS; CORTICAL-NEURONS; BOLD RESPONSE; BRAIN; ACTIVATION;
D O I
10.1002/ana.24231
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The aim of this study was to determine the frequency-dependent, spatiotemporal involvement of corticothalamic networks to the generation of absence seizures. Methods: Magnetoencephalography recordings were obtained in 12 subjects (44 seizures) with untreated childhood absence seizures. Time-frequency analysis of each seizure was performed to determine bandwidths with significant power at ictal onset. Source localization was then completed to determine brain regions contributing to generalized spike and wave discharges seen on electroencephalogram. Results: Significant power in the time-frequency analysis was seen within 1 to 20Hz, 20 to 70Hz, and 70 to 150Hz bandwidths. Source localization revealed that sources localized to the frontal cortex similarly for the low-and gamma-frequency bandwidths, whereas at the low-frequency bandwidth (3-20Hz) significantly more sources localized to the parietal cortex (odds ratio [ OR] = 16.7). Cortical sources within the high-frequency oscillation (HFO) bandwidth (70-150Hz) localized primarily to the frontal region compared to the parietal (OR = 7.32) or temporal (OR = 2.78) areas. Interpretation: Neuromagnetic activity within frontal and parietal cortical regions provides further confirmation of hemodynamic changes reported using functional magnetic resonance imaging that have been associated with absence seizures. The frequency-dependent nature of these networks has not previously been reported, and the presence of HFOs during absence seizures is a novel finding. Co-occurring frontal and parietal corticothalamic networks may interact to produce a pathological state that contributes to the generation of spike and wave discharges. The clinical and pathophysiological implications of HFOs within the frontal cortical region are unclear and should be further investigated.
引用
收藏
页码:558 / 567
页数:10
相关论文
共 50 条
  • [1] Distinct contributions of low- and high-frequency neural oscillations to speech comprehension
    Kosem, Anne
    van Wassenhove, Virginie
    [J]. LANGUAGE COGNITION AND NEUROSCIENCE, 2017, 32 (05) : 536 - 544
  • [2] Neuromagnetic high-frequency oscillations correlate with seizure severity in absence epilepsy
    Tang, Lu
    Xiang, Jing
    Huang, Shuyang
    Miao, Ailiang
    Ge, Huaiting
    Liu, Hongxing
    Wu, Di
    Guan, Qingshan
    Wu, Ting
    Chen, Qiqi
    Yang, Lu
    Lu, Xiaopeng
    Hu, Zheng
    Wang, Xiaoshan
    [J]. CLINICAL NEUROPHYSIOLOGY, 2016, 127 (02) : 1120 - 1129
  • [3] High-frequency oscillations and seizure generation in neocortical epilepsy
    Worrell, GA
    Parish, L
    Cranstoun, SD
    Jonas, R
    Baltuch, G
    Litt, B
    [J]. BRAIN, 2004, 127 : 1496 - 1506
  • [4] The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes
    Jacobs, Julia
    Vogt, Christina
    Levan, Pierre
    Zelmann, Rina
    Gotman, Jean
    Kobayashi, Katsuhiro
    [J]. CLINICAL NEUROPHYSIOLOGY, 2016, 127 (01) : 129 - 142
  • [5] High-frequency oscillations in distributed neural networks reveal the dynamics of human decision making
    Guggisberg, Adrian G.
    Dalal, Sarang S.
    Findlay, Anne M.
    Nagarajan, Srikantan S.
    [J]. FRONTIERS IN HUMAN NEUROSCIENCE, 2008, 1
  • [6] Abnormalities of Neuronal Oscillations and Temporal Integration to Low- and High-Frequency Auditory Stimulation in Schizophrenia
    Hamm, Jordan P.
    Gilmore, Casey S.
    Picchetti, Natalie A. M.
    Sponheim, Scott R.
    Clementz, Brett A.
    [J]. BIOLOGICAL PSYCHIATRY, 2011, 69 (10) : 989 - 996
  • [7] High-frequency Oscillations and the Seizure Onset Zones in Neocortical Epilepsy
    Sun Yan-Ping
    Wang Yu-Ping
    Wang Zhi-Hong
    Wu Feng-Yu
    Tang Li-Ou
    Zhang Shou-Wen
    Pei Hai-Tao
    Wang Yan
    Huang Zhao-Yang
    Xue Qing
    Xu Cui-Ping
    Tai Jun-Li
    [J]. 中华医学杂志(英文版), 2015, 128 (13) : 1724 - 1727
  • [8] High-frequency Oscillations and the Seizure Onset Zones in Neocortical Epilepsy
    Sun, Yan-Ping
    Wang, Yu-Ping
    Wang, Zhi-Hong
    Wu, Feng-Yu
    Tang, Li-Ou
    Zhang, Shou-Wen
    Pei, Hai-Tao
    Wang, Yan
    Huang, Zhao-Yang
    Xue, Qing
    Xu, Cui-Ping
    Tai, Jun-Li
    [J]. CHINESE MEDICAL JOURNAL, 2015, 128 (13) : 1724 - 1727
  • [9] High-frequency oscillations pinpoint the seizure-onset zone
    Heather Wood
    [J]. Nature Reviews Neurology, 2011, 7 (9) : 475 - 475
  • [10] Phase and amplitude coupling of high-frequency oscillations in seizure records
    Guisande Donadio, Sabrina Natali
    Pallares Di Nunzio, Monserrat
    Granado, Mauro
    Montani, Fernando
    [J]. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2021, 49 (SUPPL 1) : S131 - S132