C-kit and PDGFRA gene mutations in triple negative breast cancer

被引：1

作者：

Zhu, Yun ^{[1
]}

Wang, Yan ^{[3
]}

Guan, Bing ^{[1
]}

Rao, Qiu ^{[1
]}

Wang, Jiandong ^{[1
]}

Ma, Henghui ^{[1
]}

Zhang, Zhihong ^{[2
]}

Zhou, Xiaojun ^{[1
]}

机构：

[1] Nanjing Univ, Nanjing Jinling Hosp, Coll Med, Dept Pathol,Clin Sch, Nanjing 210002, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Pathol, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 2, Dept Pathol, Nanjing 210003, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 07期

关键词：

C-KIT; PDGFRA; mutation; triple negative breast cancer; immunohistochemical expression; GASTROINTESTINAL STROMAL TUMORS; CELL LUNG-CANCER; KINASE INHIBITOR; EXPRESSION; CARCINOMAS; DASATINIB; RECEPTOR; GROWTH; LINES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we evaluated C-kit immunohistochemical expression and C-kit and platelet derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast cancer. 171 cases were analyzed by immunohistochemical staining for the expression of C-kit and 45 cases, including 10 C-kit negative cases and 35 C-kit positive cases, were performed for C-kit gene mutations in exons 9, 11, 13 and 17 and PDGFRA gene mutations in exons 12 and 18. C-kit expression was detected in 42.1% of triple negative breast cancers. Only 1 activating mutation was detected in exon 11 of C-kit gene in 1 case. No activating mutations were found in the other 44 cases. C-kit expression is a frequent finding in triple negative breast cancers; 1 activating mutation which was also found in gastrointestinal stromal tumors was detected; a few cases might benefit from imatinib.

引用

页码：4280 / 4285

页数：6

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