Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone

被引：12

作者：

Akagi, Hiroyuki ^{[1
]}

Iwata, Munetaka ^{[1
]}

Ichinohe, Tomu ^{[1
]}

Amimoto, Hirokazu ^{[1
]}

Hayashi, Yuuta ^{[1
]}

Kannno, Nobuo ^{[1
]}

Ochi, Hiroki ^{[2
]}

Fujita, Yukihiro ^{[3
]}

Harada, Yasuji ^{[1
]}

Tagawa, Masahiro ^{[1
]}

Hara, Yasushi ^{[1
]}

机构：

[1] Nippon Vet & Life Sci Univ, Fac Vet Med, Dept Vet Sci, Div Vet Surg, Tokyo 1808602, Japan

[2] Nippon Vet & Life Sci Univ, Fac Vet Med, Dept Vet Sci, Div Vet Microbiol, Tokyo 1808602, Japan

[3] Azabu Univ, Sch Vet Med, Lab Vet Surg, Chuou Ku, Sagamihara, Kanagawa, Japan

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2014年 / 28卷 / 06期

关键词：

Biomaterial; hydroxyapatite; poly-l-lactide; foreign body reaction; orthopedics; LONG-TERM; INTERNAL-FIXATION; COMPOSITE RODS; BONE-FRACTURES; PIN FIXATION; RABBITS; BEHAVIOR; SURGERY;

D O I：

10.1177/0885328213487754

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hydroxyapatite (HA)/poly-l-lactide(PLLA) composite biomaterials are available for orthopedic applications, but bioresorption and cell-mediated inflammation in bone cortex are unknown. We conducted an 84-month follow-up study with Beagle dogs that were subjected to implants with either PLLA (left femur) or HA/PLLA (right femur). Histological and radiographic analysis showed that HA/PLLA screws induced significant increases in HA content from 36 months onward and complete burr hole closure at 60 months, whereas PLLA screws did not. Moreover, PLLA screws induced more severe fibrous tissue and histiocyte infiltration. HA/PLLA screws promote earlier burr hole replacement and have superior biocompatibility compared to PLLA screws.

引用

页码：954 / 962

页数：9

共 50 条

[1] Biocompatibility of Poly-L-lactide and hydroxyapatite composite
Bai, YJ
Lee, SY
Chang, WJ
Wang, CY
Wang, YH
Guo, BR
Tseng, H
Lin, CT
JOURNAL OF DENTAL RESEARCH, 2001, 80 (04) : 1383 - 1383
[2] Hydroxyapatite/poly-L-lactide (collagen) biocomposite with poly-L-lactide of different molecular weights
Ignjatovic, N
Plavsic, M
Uskokovic, D
ADVANCED ENGINEERING MATERIALS, 2000, 2 (08) : 511 - 514
[3] The influence of the preparation conditions and filler content on thermal properties of poly-L-lactide and hydroxyapatite/poly-L-lactide nanocomposite
Milicevic, Dejan
Suljovrujic, Edin
POLYMER INTERNATIONAL, 2017, 66 (09) : 1275 - 1283
[4] Fixation with poly-L-lactide screws in hip osteotomies
Ito, Hiroshi
Matsuno, Takeo
Minami, Akio
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2006, (444) : 169 - 175
[5] BIOCOMPATIBLE POLY-L-LACTIDE RIBERS
HYON, SH
JAMSHIDI, K
IKADA, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1983, 185 (MAR): : 52 - POLY
[6] Accelerated ageing and degradation in poly-L-lactide/hydroxyapatite nanocomposites
Delabarde, Claire
Plummer, Christopher J. G.
Bourban, Pierre-Etienne
Manson, Jan-Anders E.
POLYMER DEGRADATION AND STABILITY, 2011, 96 (04) : 595 - 607
[7] Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites
Balac, I.
Tang, C. Y.
Tsui, C. P.
Chen, D. Z.
Uskokovic, P. S.
Ignjatovic, N.
Uskokovic, D. P.
RECENT DEVELOPMENTS IN ADVANCED MATERIALS AND PROCESSES, 2006, 518 : 501 - 506
[8] Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials
Ignjatovic, N
Tomic, S
Dakic, M
Miljkovic, M
Plavsic, M
Uskokovic, D
BIOMATERIALS, 1999, 20 (09) : 809 - 816
[9] Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials
Balac, I
Uskokovic, PS
Ignjatovic, N
Aleksic, R
Uskokovic, D
COMPUTATIONAL MATERIALS SCIENCE, 2001, 20 (02) : 275 - 283
[10] A comparative study of two types of sternal pins used for sternal closure: poly-L-lactide sternal pins versus uncalcined hydroxyapatite poly-L-lactide sternal pins
Fu, Xian-ming
Oshima, Hideki
Araki, Yoshimori
Narita, Yuji
Mutsuga, Masato
Okada, Noritaka
Tsunekawa, Tomohiro
Usui, Akihiko
JOURNAL OF ARTIFICIAL ORGANS, 2013, 16 (04) : 458 - 463

← 1 2 3 4 5 →