Quercetin decrease somatic cells count in mastitis of dairy cows

被引：18
|
作者：
Burmanczuk, Artur [1 ]
Hola, Piotr [2 ]
Milczak, Andrzej [3 ]
Piech, Tomasz [4 ]
Kowalski, Cezary [1 ]
Wojciechowska, Beata [5 ]
Grabowski, Tomasz [6 ]
机构：
[1] Univ Life Sci, Fac Vet Med, Dept Pharmacol, Akad 12, PL-20033 Lublin, Poland
[2] Agromarina Sp Zoo, Kulczyn Kolonia 48, PL-22235 Hansk Pierwszy, Poland
[3] Univ Life Sci, Fac Vet Med, Dept & Clin Anim Internal Dis, Subdept Compan Anim Internal Med, Gleboka 30, PL-20612 Lublin, Poland
[4] Univ Life Sci, Fac Vet Med, Dept & Clin Anim Reprod, Gleboka 30, PL-20612 Lublin, Poland
[5] Labconsulting, Ul Dudska 9, PL-54427 Wroclaw, Poland
[6] Polpharrna Biol, Trzy Lipy 3, PL-80172 Gdansk, Poland
来源：
RESEARCH IN VETERINARY SCIENCE | 2018年 / 117卷
关键词：
Mastitis; Quercetin; Flavonoids; Immunomodulator; Inflammation; LIPOPOLYSACCHARIDE-INDUCED MASTITIS; NF-KAPPA-B; ATTENUATES INFLAMMATORY RESPONSES; SIGNALING PATHWAYS; EXPRESSION;
D O I：
10.1016/j.rvsc.2018.01.006
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Quercetin is a dietary flavonoid which has an effect on inflammation, angiogenesis and vascular inflammation. In several other flavonoids (e.g. kaempferol, astragalin, alpinetin, baicalein, indirubin), anti-inflammatory mechanism was proven by using mice mastitis model. The aim of the current study was pilot analysis of quercetin tolerability and its impact on somatic cells count (SCC) after multiple intramammary treatment on dairy cows with clinical mastitis. Based on SCC and clinical investigation, 9 dairy cows with clinical mastitis of one quarter were selected for the pilot study. Baseline analysis (hematology, TNF alpha, SCC) was performed every 24 h among all cows three days before the first dose (B1-B3). After the baseline monitoring (B1-B3) eight days treatment (D1-D8) was performed with a high and low dose. Selected blood parameters were analyzed. Starting from D1 to D8, a decrease of SCC in relation to baseline was characterized by declining trend. The presented results allowed the confirmation of the significant influence of quercetin on the reduction of SCC in mastitis in dairy cows after 8 days of therapy.
引用
收藏
页码：255 / 259
页数：5
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