Synthesis and DNA binding studies of Platinum (II) complexes Based on Cyclodextrin

被引：1
|
作者：
Tang, Siping [1 ]
Feng, Yonglan [1 ]
Xu, Zhifeng [1 ]
Wang, Deping [1 ]
机构：
[1] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China
来源：
RECENT HIGHLIGHTS IN ADVANCED MATERIALS | 2014年 / 575-576卷
关键词：
Platinum (II) complex; beta-Cyclodextrin derivatives; DNA binding; BETA-CYCLODEXTRIN; NEUTRAL CONDITIONS; ESTER HYDROLYSIS; DIMER CATALYST; AZIRIDINES;
D O I：
10.4028/www.scientific.net/KEM.575-576.280
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Mono-modified beta-cyclodextrins ligands, L-1 (6-mono-(N-aminoethyl)amino-beta-cyclodextrin) and L-2 (6-mono-(N-(pyridin-2-yl)ethylamino)-beta-cyclodextrin), and their platinum(II) complexes, 1 ([Pt(L-1)Cl-2]center dot 8H(2)O) and 2 ([Pt(L-2)Cl-2]center dot 4H(2)O), were successfully synthesized. As revealed by UV-Vis and CD spectroscopic studies, both complexes mainly adopt a non-intercalative mode with DNA. The interaction between platinum complex 1 and DNA was obviously observed in agarose Gel Electrophoresis. Meanwhile, two ligands L-1, L-2 and platinum complex 2 have no obvious interaction with DNA. The difference interaction between complexes 1, 2 and DNA should be ascribed to their different structures.
引用
收藏
页码：280 / 286
页数：7
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