Synthesis of C-14-labelled satigrel

被引：0

作者：

Tanaka, S ^{[1
]}

Yamagishi, Y ^{[1
]}

Kusano, K ^{[1
]}

Yoshimura, T ^{[1
]}

机构：

[1] EISAI & CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1996年 / 38卷 / 05期

关键词：

anti-platelet aggregation agent; C-14-labelled satigrel; 4-cyano-5-(4'-methoxy[ring-U-C-14]phenyl)-5-(4''-methoxyphenyl)-4-pentenoic acid; synthesis;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

C-14-Labelled satigrel, or 4-cyano-5-(4'-methoxy [ring-U-C-14] phenyl)-5-(4 ''-methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4, 4'-dimethoxy [ring-U-C-14] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 mu Ci)/mg and 98.8%, respectively.

引用

页码：435 / 440

页数：6

共 50 条

[1] SYNTHESIS AND ABSORPTION OF P-32-LABELLED AND C-14-LABELLED LECITHINS
WAGNER, H
[J]. ARCHIV DER PHARMAZIE UND BERICHTE DER DEUTSCHEN PHARMAZEUTISCHEN GESSELSCHAFT, 1970, 303 (04): : B136 - &
[2] SYNTHESIS OF C-14-LABELLED 1,4-DIPHENYLBUTANE
JOHNSON, P
POVER, WFR
MCWEENY, DJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1962, (DEC): : 4926 - &
[3] A BIOSYNTHESIS OF C-14-LABELLED GLYCOGEN
HASSETT, CC
SUMMERSON, WH
SOLOMON, F
[J]. NUCLEONICS, 1954, 12 (04): : 59 - 60
[4] PHYTOSYNTHESIS OF C-14-LABELLED RUTOSIDE
MICHAUD, J
LAPARRA, J
LESCA, MF
HARMAND, MF
MASQUELI.J
BLANQUET, P
[J]. ANNALES PHARMACEUTIQUES FRANCAISES, 1969, 27 (12): : 767 - &
[5] STUDIES WITH C-14-LABELLED GLIBENCLAMIDE
ANDERSON, J
STEPHENSON, RJ
TOMLINSON, RW
WEINBERG, AL
[J]. POSTGRADUATE MEDICAL JOURNAL, 1970, 46 : 42 - +
[6] NEW SYNTHESIS FOR PREPARATION OF C-14-LABELLED ALKALI CYANIDES
BANFI, D
MLINKO, S
PALAGYI, T
[J]. JOURNAL OF LABELLED COMPOUNDS, 1971, 7 (03): : 221 - &
[7] REACTION OF PEPSIN WITH C-14-LABELLED SUBSTRATES
GODIN, C
YUAN, CY
[J]. JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1970, (02): : 84 - &
[8] THE FATE OF C-14-LABELLED IPRONIAZID IN THE RAT
NAIR, V
[J]. BIOCHEMICAL PHARMACOLOGY, 1960, 3 (01) : 78 - 80
[9] METABOLISM AND EXCRETION OF C-14-LABELLED DIETHYLCARBAMAZINE
BANGHAM, DR
[J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1955, 10 (04): : 397 - 405
[10] PHARMACOKINETIC STUDIES WITH C-14-LABELLED PIRAZOCILLIN
CSANYI, E
ELEKES, I
KOCZKA, I
[J]. ACTA PHYSIOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE, 1971, 39 (1-3): : 277 - &

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